Advertisement

Diabetologia

, Volume 24, Issue 1, pp 10–12 | Cite as

Diabetic nephropathy and arterial hypertension

  • H. -H. Parving
  • A. R. Andersen
  • U. M. Smidt
  • B. Oxenbøll
  • B. Edsberg
  • J. Sandahl Christiansen
Originals

Summary

The relationship between arterial blood pressure and diabetic nephropathy was examined in 61 Type 1 (insulin-dependent) diabetic patients (22 females and 39 males). All patients fulfilled the following criteria: persistent proteinuria (>0.5g/day), onset of diabetes before 31 years of age, age <42 years, serum creatinine <130 μmol/l, and no antihypertensive treatment. Thirty Type 1 diabetic patients without persistent proteinuria but matched for sex, age, ideal body weight and duration of diabetes, and 30 healthy subjects matched for sex, age and ideal body weight were also studied as controls. The diabetic patients with persistent proteinuria had elevated blood pressures (146/96±17/10 mmHg, mean±SD) compared with 123/75±11/8 mmHg in diabetic patients without persistent proteinuria, and normal subjects (120/77±6/6 mmHg; p<0.001 for each). Diastolic blood pressure ⩾95 mmHg was found in 51% of the group with persistent proteinuria. Elevated arterial blood pressure is frequently present in young Type 1 diabetic patients with diabetic nephropathy and normal serum creatinine.

Key words

Type 1 diabetes diabetic nephropathy hypertension proteinuria serum creatinine 

References

  1. 1.
    Honey GE, Pryse-Davies J, Roberts DM (1962) A survey of nephropathy in young diabetics. Q J Med 31: 473–483Google Scholar
  2. 2.
    Thomsen AC (1965) The kidney in diabetes mellitus. Munksgaard, CopenhagenGoogle Scholar
  3. 3.
    Knowles HC (1974) Magnitude of the renal failure problem in diabetes. Kidney Int (Suppl) 6: 2–7Google Scholar
  4. 4.
    Ireland JT, Viberti GC, Watkins PJ (1982) The kidney and renal tract. In: Keen H, Jarrett J (eds) Complications of diabetes, 2nd eds. Edward Arnold, London, pp 166–172Google Scholar
  5. 5.
    Deckert T, Poulsen JE, Larsen M (1978) Prognosis of diabetics with diabetes onset before the age of thirty-one. Diabetologia 14: 363–370Google Scholar
  6. 6.
    Watkins PJ, Blainey JD, Brewer DB, Fitzgerald MG, Malins JM, O'Sullivan DJ, Pinto JA (1972) The natural history of diabetic renal disease. Q J Med 41: 437–456Google Scholar
  7. 7.
    Leading article (1978) Diabetes and hypertension. Lancet 2: 138–139Google Scholar
  8. 8.
    Parving H-H, Smidt UM, Friisberg B, Bonnevie-Nielsen V, Andersen AR (1981) A prospective study of glomerular filtration rate and arterial blood pressure in insulin-dependent diabetics with diabetic nephropathy. Diabetologia 20: 457–461Google Scholar
  9. 9.
    Larsen K (1972) Creatinine assay by a reaction-kinetic principle. Clin Chim Acta 41: 209–217Google Scholar
  10. 10.
    Laipply TC, Eitzen O, Dutra FR (1944) Intercapillary glomerulosclerosis. Arch Int Med 74: 354–364Google Scholar
  11. 11.
    Henderson LL, Spraue RG, Wagener HP (1947) Intercapillary glomerulosclerosis. Am J Med 3:131–144Google Scholar
  12. 12.
    Mendelow H, Britt G (1956) Intercapillary glomerulosclerosis. Aclinico-pathologic study. J Mt Sinai Hosp 23: 663–670Google Scholar
  13. 13.
    Bjerkelund CJ (1951) Diabetic renal disease. Acta Med Scand 139: 133–145Google Scholar
  14. 14.
    Malins J (1968) Clinical diabetes mellitus. Eyre and Spottiswoode, London, pp 152–185Google Scholar
  15. 15.
    Hatch FE, Watt MF, Kramer NC, Parrish AE, Howe JS (1961) Diabetic glomerulosclerosis. Am J Med 31: 216–230Google Scholar
  16. 16.
    Freedman P, Moulton R, Spencer AG (1958) Hypertension and diabetes mellitus. Q J Med 27: 293–305Google Scholar
  17. 17.
    Keen H, Track NS, Clive Sowry GS (1975) Arterial pressure in clinically apparent diabetics. Diabet Metabol (Paris) 1: 159–178Google Scholar
  18. 18.
    Deckert T, Poulsen JE (1981) Diabetic nephropathy: Fault or destiny? Diabetologia 21: 178–183Google Scholar
  19. 19.
    Christlieb AR (1973) Diabetes and hypertensive vascular disease. Am J Cardiol 32: 592–606Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • H. -H. Parving
    • 1
    • 2
    • 5
  • A. R. Andersen
    • 1
    • 3
  • U. M. Smidt
    • 5
  • B. Oxenbøll
    • 1
  • B. Edsberg
    • 4
  • J. Sandahl Christiansen
    • 1
  1. 1.Steno Memorial HospitalGentofteDenmark
  2. 2.Department of Medicine FHerlev Hospital, University of CopenhagenCopenhagenDenmark
  3. 3.Department of Medicine BHerlev Hospital, University of CopenhagenCopenhagenDenmark
  4. 4.Department of Medicine CBispebjerg HospitalCopenhagenDenmark
  5. 5.Department of Clinical PhysiologyBispebjerg HospitalCopenhagenDenmark

Personalised recommendations