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Diabetologia

, Volume 27, Supplement 1, pp 116–117 | Cite as

Genetic polymorphism of the fourth component of complement and type 1 (insulin-dependent) diabetes

  • A. Marcelli-Barge
  • J. C. Poirier
  • M. Schmid
  • I. Deschamps
  • H. Lestradet
  • P. Prevost
  • J. Hors
Article

Summary

The complement proteins, Bf, C2, C4A and C4B, are closely linked to HLA. In 74 propositi and their families, and 97 controls genotyped for HLA-A, -B, -C, -DR, -Bf, a high incidence of the C4BQ0 variant was detected in the patient group (33% versus 12%, p< 0.00001); C4BQ0 was more frequent in propositi than in non-affected siblings (40 out of 74 versus 36 out of 92, p<0.05). When comparing the distribution of the phenotype C4BQ0 in Type 1 diabetic patients and normal control subjects, the difference was significant in patients bearing DR3 or DR4 (56% and 25%, respectively, p< 0.003). The main linkage disequilibria were observed among the 74 propositi: B18, BfF1, C4, A3, BQ0, DR3; B12, BfS, C4, A3, BQ0, DR4. The existence of a silent allele at the C4 B locus is known to be associated with a defective immune response.

Key words

HLA complement Type 1 diabetes 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • A. Marcelli-Barge
    • 1
  • J. C. Poirier
    • 1
  • M. Schmid
    • 1
  • I. Deschamps
    • 2
  • H. Lestradet
    • 2
  • P. Prevost
    • 1
  • J. Hors
    • 1
  1. 1.Inserm U 93, Hôpital Saint LouisParisFrance
  2. 2.Inserm U 83, Hôpital HéroldParisFrance

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