Diabetologia

, Volume 31, Issue 10, pp 762–765

Is resistance to ischaemic conduction failure induced by hypoxia?

  • E. A. Masson
  • S. E. Church
  • A. A. Woodcock
  • S. P. Hanley
  • A. J. M. Boulton
Originals

Summary

Resistance to ischaemic conduction failure is a recognised but unexplained property of diabetic peripheral nerve. We have studied matched groups of control, diabetic, and non-diabetic hypoxic subjects (hypoxia: arterial oxygen tension ⩽ 60 mm Hg (8 kPa) on at least one occasion and secondary to chronic lung disease). Similar resistance to ischaemia was seen in the hypoxic and diabetic groups compared with control subjects (p<0.001). The degree of resistance correlated with arterial oxygen tension at the time of testing (r = 0.72, p<0.01). In all individuals with acute exacerbations of hypoxia, the resistance to ischaemia was normalised with improvement of respiratory function (p<0.02). These results are compatible with the hypothesis that endoneurial hypoxia may be a factor in the pathogenesis of diabetic neuropathy.

Key words

Diabetes neuropathy hypoxia ischaemia ischaemia resistance 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • E. A. Masson
    • 1
  • S. E. Church
    • 1
  • A. A. Woodcock
    • 2
  • S. P. Hanley
    • 3
  • A. J. M. Boulton
    • 1
  1. 1.Manchester Royal InfirmaryUK
  2. 2.Wythenshawe HospitalUK
  3. 3.Monsall HospitalManchesterUK

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