Theoretical and Applied Genetics

, Volume 74, Issue 3, pp 409–413 | Cite as

Analysis of lethals in selected lines of Drosophila melanogaster

  • A. Domínguez
  • J. Albornoz
  • E. Santiago


Five lines of Drosophila melanogaster that reached an extreme phenotype after long-term selection for increased dorsocentral bristle number, were analysed for the presence of lethals. Seven chromosome II and three chromosome III lethal types were detected in four of the lines, at frequencies ranging from between 6% and 36%. No lethal had any demonstrable effect over the selected trait. In one line, where almost every chromosome II was a lethal carrier, it was shown that the main lethal (at a frequency of 36%) was associated with the transmission ratio distortion in males. The processes which could lead to the accumulation of this lethal and others linked in disequilibrium to it is discussed. Some results suggest similar mechanisms for the accumulation of lethals in the other lines. These findings show that causes other than the direct effect of artificial selection must be taken into account when trying to explain the accumulation of lethals in selected lines.

Key words

Artificial selection Lethals Segregation distortion Dorsocentral bristle number Drosophila melanogaster 


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  1. Clayton GA, Robertson A (1957) An experimental check on quantitative genetical theory. II. The long-term effect of selection. J Genet 55:152–170Google Scholar
  2. Frankham R, Jones LP, Barker JSF (1968) The effects of population size and selection intensity in selection for a quantitative character in Drosophila melanogaster. III. Analyses of the lines. Genet Res 12:267–283Google Scholar
  3. García-Dorado A, López-Fanjul C (1983) Accumulation of lethals in highly selected lines of Drosophila melanogaster. Theor Appl Genet 66:221–223Google Scholar
  4. Hartl DL, Hiraizumi Y (1976) Segregation distortion. In: Ashburner M, Novitski E (eds) The genetics and biology of Drosophila, vol 1 b. Academic Press, London, pp 615–666Google Scholar
  5. Hollingdale B (1971) Analyses of some genes from abdominal bristle number selection lines in Drosophila melanogaster. Theor Appl Genet 41:292–301Google Scholar
  6. Kidwell MG, Kidwell JF, Sved JA (1977) Hibrid dysgenesis in Drosophila melanogaster: a syndrome of aberrant traits including mutation, sterility and male recombination. Genetics 86:813–833Google Scholar
  7. Lindsley DL, Grell EH (1968) Genetic variations of Drosophila melanogaster. Carnegie Institution Washington, 627Google Scholar
  8. Mackay TFC (1984). Jumping genes meet abdominal bristles: hybrid dysgenesis-induced quantitative variation in Drosophila melanogaster. Genet Res 44:231–237Google Scholar
  9. Madalena FE, Robertson A (1975) Population structure in artificial selection: studies with Drosophila melanogaster. Genet Res 24:113–126Google Scholar
  10. Pasyukova EG, Belyaeva ESp, Kogan GL, Kaidanov LZ, Gvozdev VA (1986) Concerted transpositions of mobile genetic elements coupled with fitness changes in Drosophila melanogaster. Mol Biol Evol 3:299–312Google Scholar
  11. Reeve ECR, Robertson FW (1983) Studies in quantitative inheritance. II. Analysis of a strain of Drosophila melanogaster selected for long-wing. J Genet 51:276–316Google Scholar
  12. Skibinski DOF (1986) Study of lethals in selection lines in Drosophila melanogaster. J Hered 77:31–34Google Scholar
  13. Yoo BH (1980) Long-term selection for a quantitative character in large replicate populations of Drosophila melanogaster. II. Lethals and visible mutants with large effects. Genet Res 35:19–31Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Domínguez
    • 1
  • J. Albornoz
    • 1
  • E. Santiago
    • 1
  1. 1.Departamento de GenéticaUniversidad de OviedoOviedoSpain

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