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Molecular and General Genetics MGG

, Volume 103, Issue 3, pp 218–222 | Cite as

Antibiotics and infectious hybrid sterility in Drosophila paulistorum

  • Lee Ehrman
Article

Summary

Santa Marta and Mesitas (Colombia) strains of Drosophila paulistorum produce, when crossed, sterile males in the F1 and in several backcross generations. The antibiotics toyocamycin nucleoside and gliotoxin (100 μg/ml) were ingested by female parents produced from eggs deposited upon and developed in drug-impregnated medium. The proportions of males capable of developing motile sperm in the hybrids are higher in the progenies of drugtreated mothers than in the controls. Toyocamycin and gliotoxin apparently retard the growth of the cytoplasmic factor (a virus or a rickettsia) which causes the maternally transmitted sterility of these hybrid males.

Keywords

Nucleoside Sterile Male Colombia Female Parent Motile Sperm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature

  1. Brockman, R. W., and E. P. Anderson: Biochemistry of cancer. Ann. Rev. Biochem. 32, 463–512 (1963).Google Scholar
  2. Compans, R. W., and P. W. Choppin: The length of the helical nucleocapsid of Newcastle disease virus. Virology 33, 344–346 (1967).Google Scholar
  3. Dobzhansky, Tsch., and O. Pavlovsky: Experiments on the incipient species of the Drosophila paulistorum complex. Genetics 55, 141–156 (1967).Google Scholar
  4. Ehrman, L.: The genetics of hybrid sterility in Drosophila paulistorum. Evolution 14, 212–223 (1960).Google Scholar
  5. —: Apparent cytoplasmic sterility in Drosophila paulistorum. Proc. nat. Acad. Sci. (Wash.) 49, 155–157 (1963).Google Scholar
  6. —: A study of infectious hybrid sterility in Drosophila paulistorum. Proc. nat. Acad. Sci. (Wash.) 58, 195–198 (1967).Google Scholar
  7. Johnson, J. R., W. F. Bruce, and J. D. Dutcher: The antibiotic principle of Gliocladium fimbriatum. J. Amer. chem. Soc. 65, 2005–2009 (1943).Google Scholar
  8. Kastritsis, C. D.: A comparative study of the chromosomal polymorphs in the incipient species of the Drosophila paulistorum complex. Chromosoma (Berl.) 23, 180–202 (1967).Google Scholar
  9. Kernaghan, R. P., and L. Ehrman: Filamentous inclusions in the paragonia of Drosophila paulistorum. J. invert. Path. 10, 432–434 (1968).Google Scholar
  10. King, R. C.: Widespread occurrence of a symbiont in Drosophila. Drosophila Information Service 43, 154 (1968).Google Scholar
  11. Matthews, R. E. F.: Biosynthetic incorporation of metabolic analogues. Pharmacol. Rev. 10, 359–406 (1958).Google Scholar
  12. Miller, P. A., K. P. Milstrey, and P. W. Trown: Specific inhibition of viral ribonucleic acid replication by gliotoxin. Science 159, 431–432 (1968).Google Scholar
  13. Ohba, S.: Chromosomal polymorphism and capacity for increase under near optimal conditions. Heredity 22, 169–186 (1967).Google Scholar
  14. Spassky, B.: Cream of wheat-molasses fly medium. Drosophila Information Service 17, 67–68.Google Scholar
  15. Tander, B., D. L. Williamson, and L. Ehrman: Unusual filamentons structures in the paragonia of male Drosophila. J. Cell Biol. 38, 329–336 (1968).Google Scholar
  16. Tavitan, A., S. C. Uretsky, and G. Acs: Selective inhibition of ribosomal RNA synthesis in mammalian cells. Biochim. biophys. Acta (Amst.) 157, 33–42 (1968).Google Scholar
  17. Williamson, D. L., and L. Ehrmann: Induction of hybrid sterility in nonhybrid males of Drosophila paulistorum. Genetics 55, 131–140 (1967).Google Scholar
  18. Wolstenholme, D. R.: A DNA and RNA-containing cytoplasmic body in Drosophila melanogaster and its relation to flies. Genetics 52, 949–975 (1965).Google Scholar
  19. Yanders, A. F., J. G. Brewen, W. J. Peacock, and D. J. Goodchild: Meiotic drive and visible polarity in Drosophila spermatocytes. Genetics 59, 245–253 (1968).Google Scholar

Copyright information

© Springer-Verlag 1968

Authors and Affiliations

  • Lee Ehrman
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA

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