Human Genetics

, Volume 70, Issue 2, pp 181–182 | Cite as

Bovine superoxide dismutase in Fanconi anaemia. Therapeutic trial in two patients

  • V. Izakovič
  • E. Štrbáková
  • E. Kaiserová
  • P. Križan
Short Communications


Bovine superoxide dismutase (SOD) (Peroxinorm, Grünenthal Stolberg) was injected intramuscularly or subcutaneously in a daily dose of 4 mg over a period of six weeks into two patients with Fanconi anaemia. The effects (measured by the decrease of chromosome aberrations in blood lymphocytes and the increase in blood cells in venous blood) were evident but temporary. The hypothetical mode of action of SOD and the failure of a prolonged therapeutic effect are discussed.


Internal Medicine Blood Cell Superoxide Superoxide Dismutase Therapeutic Effect 
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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • V. Izakovič
    • 1
  • E. Štrbáková
    • 2
  • E. Kaiserová
    • 2
  • P. Križan
    • 3
  1. 1.Department of Clinical GeneticsInstitute for Postgraduate Medical EducationBratislavaUSSR
  2. 2.Paediatric Department of Institute of National HealthBratislavaUSSR
  3. 3.Paediatric Department of State Institute of National HealthBratislavaUSSR

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