Human Genetics

, Volume 67, Issue 2, pp 183–186

Estimating the Recombination frequency for the PTC-Kell linkage

  • M. Anne-Spence
  • Catherine T. Falk
  • Katherine Neiswanger
  • L. Leigh Field
  • Mary L. Marazita
  • F. H. AllenJr.
  • Roger M. Siervogel
  • Alex F. Roche
  • Barbara F. Crandall
  • Robert S. Sparkes
Original Investigations

Summary

Two data sets are analyzed for linkage between the PTC and Kell blood group loci. The original report of close linkage for these loci was that of Conneally et al. (1976), where the maximum likelihood estimate of Θ was 0.05. These two new data sets give a combined maximum likelihood estimate of \(\hat \Theta\)m=f=0.28. Estimating the recombination frequency for the sexes separately gave \(\hat \Theta\)m=0.29, \(\hat \Theta\)f=0.23. The combined maximum likelihood estimate over all published data sets including this report is \(\hat \Theta\)m=f=0.14, \(\hat {\rm Z}\)max=8.94. There is statistically significant evidence of heterogeneity among the published studies.

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • M. Anne-Spence
    • 1
  • Catherine T. Falk
    • 2
  • Katherine Neiswanger
    • 1
  • L. Leigh Field
    • 3
  • Mary L. Marazita
    • 1
  • F. H. AllenJr.
    • 2
  • Roger M. Siervogel
    • 4
  • Alex F. Roche
    • 4
  • Barbara F. Crandall
    • 1
  • Robert S. Sparkes
    • 1
  1. 1.Division of Medical Genetics, Department of Psychiatry, Medicine, Pediatrics and BiomathematicsUCLA School of MedicineLos AngelesUSA
  2. 2.Lindsley F. Kimball Research Institute of the New York Blood CenterNew YorkUSA
  3. 3.Medical Genetics ClinicAlberta Children's HospitalCalgaryCanada
  4. 4.Department of Pediatrics, Fels Research InstituteWright State UniversityYellow SpringsUSA
  5. 5.MR Unit/NPILos AngelesUSA

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