Human Genetics

, Volume 77, Issue 2, pp 142–144 | Cite as

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

  • D. F. Callen
  • E. Baker
  • R. N. Simmers
  • R. Seshadri
  • I. B. Roninson
Original Investigations


Multiple drug resistance has been shown to be associated with amplification/increased expression of a gene designated MDR. The localization of one member of the MDR gene family, MDR1, to the long arm of chromosome 7 by in situ hybridization is reported.


Internal Medicine Gene Family Resistance Gene Drug Resistance Metabolic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Chabner BA (1986) The oncologic end game. J Clin Oncol 4:625–638Google Scholar
  2. Chen C-j, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Robinson IB (1986) Internal duplication and homology with bacterial transport proteins in mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47:381–389Google Scholar
  3. Farrall M, Watson G, Bates G, Bell G, Bell J, Davies KA, Estivill X, Krüger H, Law H-Y, Lench N, Lissens W, Simon P, Scambler P, Stanier P, Vassart G, Worrall C, Williamson R, Wainwright BJ (1986) Further data supporting linkage between cystic fibrosis and the met oncogene and haplotype analysis with MET and p(J)3.11. Am J Hum Genet 39:713–719Google Scholar
  4. Fojo A, Lebo R, Shimizu N, Chin JE, Roninson IB, Merlino GT, Gottesman MM, Pastan I (1986) Localization of multidrug resistance-associated DNA sequences to human chromosome 7. Somat Cell Mol Genet 12:415–420Google Scholar
  5. Gerlach JH, Endicott JA, Juranka PF, Henderson G, Sarangi F, Deuchars KL, Ling V (1986). Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance. Nature 324:485–489Google Scholar
  6. Gros P, Croop J, Housman D (1986a) Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47:371–380Google Scholar
  7. Gros P, Croop J, Roninson IB, Varshavsky A, Housman DE (1986b) Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci USA 83:337–341Google Scholar
  8. Gros P, Neriah YB, Croop JM, Housman DE (1986c) Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 323:728–731Google Scholar
  9. ISCN (1985) An international system for human cytogenetic nomenclature. Birth Defects: Original Article Ser 21, no 1; Cytogenet Cell GenetGoogle Scholar
  10. Juliano RL, Ling V (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455:152–162Google Scholar
  11. Kartner N, Evernden-Porelle D, Bradley G, Ling V (1985) Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316:820–823Google Scholar
  12. Riordan JR, Deuchars K, Kartner N, Alon N, Trent J, Ling V (1985) Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316:817–819Google Scholar
  13. Roninson IB, Abelson HT, Housman DE, Howell N, Varshavsky A (1984) Amplification of specific DNA sequences correlates with multidrug resistance in Chinese hamster cells. Nature 309:626–628Google Scholar
  14. Roninson IB, Chin JE, Choi K, Gros P, Housman DE, Fojo A, Shen D-w, Gottesman MM, Pastan I (1986) Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci USA 83:4538–4542Google Scholar
  15. Scotto KW, Biedler JL, Melera PW (1986) Amplification and expression of gene associated with multidrug resistance in mammalian cells. Science 232:751–755Google Scholar
  16. Shen D-w, Fojo A, Chin JE, Roninson IB, Richert N, Pastan I, Gottesman MM (1986) Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science 232:643–645Google Scholar
  17. Simmers RN, Stupans I, Sutherland GR (1986) Localization of the human haptoglobin genes distal to the fragile site at 16q22 using in situ hybridization Cytogenet Cell Genet 41:38–41Google Scholar
  18. Ueda K, Cornwell MM, Gottesman MM, Pastan I, Roninson IB, Ling V, Riordan JR (1986) The mdr1 gene, responsible for multidrug resistance, codes for P-glycoprotein. Biochem Biophys Res Commun 141:956–962Google Scholar
  19. Van der Bliek AM, Van der Velde-Koerts T, Ling V, Borst P (1986) Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol 6:1671–1678Google Scholar
  20. Zabel BU, Naylor SL, Sakaguchi AY, Bell GI, Shows TB (1983) High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization. Proc Natl Acad Sci USA 80:6932–6936Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • D. F. Callen
    • 1
  • E. Baker
    • 1
  • R. N. Simmers
    • 1
  • R. Seshadri
    • 2
  • I. B. Roninson
    • 3
  1. 1.Cytogenetics Unit, Department of HistopathologyAdelaide Children's HospitalNorth AdelaideAustralia
  2. 2.Department of HaematologyFlinders Medical CentreBedford ParkAustralia
  3. 3.Center for GeneticsUniversity of Illinois at ChicagoChicagoUSA

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