Advertisement

European Journal of Nuclear Medicine

, Volume 5, Issue 3, pp 299–301 | Cite as

Accumulation of Tc-99m phosphonate complexes in metastatic lesions from colon and lung carcinomas

  • E. Edmund Kim
  • Peggy A. Domstad
  • Young Chul Choy
  • Frank H. DeLand
Case Reports

Abstract

Cases are presented in which Tc-99m methylene diphosphonate accumulated in a lung metastasis from well differentiated adenocarcinoma of the colon, and in a hepatic metastasis from oat cell carcinoma of the lung. To our knowledge, this is the first report of Tc-99m phosphonate complexes concentrated in a pulmonary metastasis of colonic carcinoma or in a hepatic metastasis of oat cell lung carcinoma. The exact mechanism for this non-osseous uptake of bone scanning agents is still unknown.

Keywords

Carcinoma Cell Carcinoma Adenocarcinoma Nuclear Medicine Lung Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alfrey, A.C., Solomons, C.C., Cirillo, J., Miller, N.L.: Extraosseous calcification: Evidence of abnormal pyrophosphate metabolism in uremia. J. Clin. Invest. 57, 692–695 (1976)Google Scholar
  2. Chaudhuri, T.K., Chaudhuri, T.K., Christie, J.H.: Tumor uptake of Tc-99m polyphosphonate: Its similarity with Sr-87m citrate and dissimilarity with Ga-67 citrate. J. Nucl. Med. 15, 458–459 (1974)Google Scholar
  3. Garcia, A.C., Yeh, S.D.J., Benua, R.S.: Accumulation of bone-seeking radionuclides in liver metastasis from colon carcinoma. Clin. Nucl. Med. 2, 265–269 (1977)Google Scholar
  4. McLaughlin, A.F.: Uptake of Tc-99m bone scanning agent by lungs with metastatic calcification. J. Nucl. Med. 16, 322–323 (1975)Google Scholar
  5. Raghavendra, B.N., McCauley, D.I., Passalaqua, A.M., Braunstein, P.: Bone scanning in metastatic calcification to the lungs. Clin. Nucl. Med. 2, 272–273 (1977)Google Scholar
  6. Robbins, S.L.: Cell injury and cell death. In: Pathologic basis of disease, pp. 51–52. Philadelphia: W.B. Saunders Co. 1974Google Scholar
  7. Schultz, M.M., Morales, J.O., Fishbein, P.G., Steinberg, A.J.: Bilateral breast uptake of Tc-99m polyphosphate in a patient with metastatic adeno-carcinoma. Radiology 118, 377–378 (1976)Google Scholar
  8. Wilkinson, R.H., Gaede, J.T.: Concentration of Tc-99m methylene diphosphate in hepatic metastases from squamous cell carcinoma. J. Nucl. Med. 20, 303–305 (1979)Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • E. Edmund Kim
    • 1
    • 2
  • Peggy A. Domstad
    • 1
    • 2
  • Young Chul Choy
    • 1
    • 2
  • Frank H. DeLand
    • 1
    • 2
  1. 1.University of Kentucky Medical CenterLexingtonUSA
  2. 2.Veterans Administration Medical CenterLexingtonUSA

Personalised recommendations