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Child's Nervous System

, Volume 2, Issue 3, pp 130–133 | Cite as

Evaluation of cerebral blood flow and metabolism in childhood moyamoya disease: an investigation into “re-build-up” on EEG by positron CT

  • Motonobu Kameyama
  • Reizo Shirane
  • Yuji Tsurumi
  • Akira Takahashi
  • Satoru Fujiwara
  • Jiro Suzuki
  • Masatoshi Ito
  • Tatsuo Ido
Original Papers

Abstract

The cerebral blood flow and cerebral metabolic rate of oxygen (CBF and CMRO2) of three cases of childhood moyamoya disease were examined by positron-emission-computed tomography for the purpose of investigating the mechanism of the “re-build-up” phenomenon on EEG. Decrease in both CBF and CMRO2 were observed following hyperventilation. However, dissociation between the decrease in CBF and CMRO2 was also observed. Arterial blood-gas analysis disclosed hypocapnea during hyperventilation and hypoxia following hyperventilation. These results clearly indicate that the re-build-up seen on EEG is the manifestation not only of ischemic hypoxia but also of hypoxic hypoxia characteristically seen in moyamoya disease.

Key words

Moyamoya disease Cerebral blood flow Cerebral metabolism Re-build-up EEG Positron CT 

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References

  1. 1.
    Endo H, Oikawa T, Yukawa H, Saiki I, Kanaya H (1981) Regional cerebral blood flow in patients with moyamoya disease. Proceedings of the 10th Japanese Conference on Surgery of Cerebral Stroke. Neuron, Tokyo, pp 179–183Google Scholar
  2. 2.
    Fracowiak RS, Lenzi GL, Jones T, Heather JD (1980) Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure and normal values. J Comput Assist Tomogr 4:727–736CrossRefGoogle Scholar
  3. 3.
    Kodama N, Aoki Y, Hiraga H, Wada T, Suzuki J (1979) Electroencephalographic findings in children with moyamoya disease. Arch Neurol 36:16–19CrossRefGoogle Scholar
  4. 4.
    Nishimoto A, Onbe H, Ueta K (1979) Clinical cerebral blood flow study in moyamoya disease with TIA. Acta Neurol Scand [Suppl 72] 60:434–435Google Scholar
  5. 5.
    Ogawa A, Kogure T, Fujiwara S, Kodama N, Suzuki J, Sakurai Y, Wada N (1981) Regional cerebral blood flow on moyamoya disease — study with 133Xe intravenous injection method. Proceedings of the 10th Japanese Conference on Surgery of Cerebral Stroke. Neuron, Tokyo, pp 189–194Google Scholar
  6. 6.
    Ohta H, Ito Z, Suzuki A, Tominaga S, Uemura K (1981) Regional cerebral blood flow in moyamoya disease evaluated by 133Xe intracarotid injection method. Proceedings of the 10th Japanese Conference on Surgery of Cerebral Stroke. Neuron, Tokyo, pp 167–173Google Scholar
  7. 7.
    Ohyama H, Niizuma H, Fujiwara S, Suzuki J (1985) EEG findings in moyamoya disease in children — concerning the causal genesis of re-build-up. Neurol Surg 13:727–733Google Scholar
  8. 8.
    Phelps ME, Hoffman EF, Huang SC, Kuhl DE (1978) A new computerized tomographic imaging system for positron-emitting radiopharmaceuticals. J Nucl Med 19:635–647PubMedGoogle Scholar
  9. 9.
    Suzuki J, Kodama N (1983) Moyamoya disease — a review. Stroke 14:104–109CrossRefGoogle Scholar
  10. 10.
    Suzuki J, Takaku A (1969) Cerebral vascular “moyamoya” disease. A disease showing abnormal net-like vessels in the base of the brain. Arch Neurol 20:288–289CrossRefGoogle Scholar
  11. 11.
    Suzuki J, Kowada M, Asahi M, Takaku A (1963) A study on disease showing singular cerebral-angiographical findings which seem to be new collateral circulation. Presented at the 22nd Meeting of the Japanese Neurosurgical Society, Osaka, September, 1963Google Scholar
  12. 12.
    Suzuki J, Takaku A, Kodama N, Sato S (1975) An attempt to treat cerebrovascular moyamoya disease in children. Child's Brain 1:193–206PubMedGoogle Scholar
  13. 13.
    Takahashi A, Fujiwara S, Suzuki J (1985) Cerebral angiography following hyperventilation in moyamoya disease — in reference to the “re-build up” phenomenon on EEG. Neurol Surg 13:255–264Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Motonobu Kameyama
    • 1
  • Reizo Shirane
    • 1
  • Yuji Tsurumi
    • 1
  • Akira Takahashi
    • 1
  • Satoru Fujiwara
    • 1
  • Jiro Suzuki
    • 1
  • Masatoshi Ito
    • 2
  • Tatsuo Ido
    • 3
  1. 1.Division of Neurosurgery, Institute of Brain DiseasesTohoku University School of MedicineSendaiJapan
  2. 2.Department of Radiology and Nuclear Medicine, Research Institute for Tuberculosis and CancerTohoku University School of MedicineSendaiJapan
  3. 3.Division of Radioisotope Research, Cyclotron Radioisotope CenterTohoku University School of MedicineSendaiJapan

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