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Child's Nervous System

, Volume 3, Issue 6, pp 354–360 | Cite as

Medulloblastomas in childhood: histological factors influencing patients' outcome

  • Katsushi Taomoto
  • Tadanori Tomita
  • Anthony J. Raimondi
  • Jan E. Leestma
Original Papers

Abstract

Sixty-five medulloblastomas in infancy and childhood treated from 1965 through 1981 were reviewed, and the correlation between histological findings of medulloblastomas and clinical course of the patients was studied. Thirty-five patients died but the remaining 30 are alive and without clinical evidence of recurrence 5 years or more after surgery. Certain histological features on light microscopic examinations (e.g., pleomorphism of tumor cells, nuclear-cytoplasmic ratio, mitotic index, degree of vascularity and endothelial proliferation) do influence patient outcome with statistical significance (P<0.05). Thirty out of 65 medulloblastomas were examined further, using immunohistochemical methods with glial fibrillary acidic protein (GFAP), neuron specific enolase (NSE), and factor VIII/vW factor (F VIII/vWF). GFAP stain was negative in 20%, NSE stain in 13.3% and F VIII/vWF stain in 16.7% of the medulloblastomas studied. “Desmoplastic” medulloblastomas showed a strong tendency toward positive NSE and GFAP staining in the glomerular portion. There was no correlation between patient outcome and the results of applied immunohistochemical studies. Our data indicate that certain histological features may influence patient outcome, but the degree and pattern of cellular differentiation do not predict outcome.

Key words

Brain neoplasms Medulloblastoma Immunohistochemistry Glial fibrillary acidic protein Neuron-specific enolase Factor VIII/von Willebrand factor 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Katsushi Taomoto
    • 1
  • Tadanori Tomita
    • 1
  • Anthony J. Raimondi
    • 1
  • Jan E. Leestma
    • 2
  1. 1.Division of Pediatric NeurosurgeryChildren's Memorial Hospital and Northwestern University Medical SchoolChicagoUSA
  2. 2.Department of PathologyChildren's Memorial Hospital and Northwestern University Medical SchoolChicagoUSA

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