Medulloblastomas in childhood: histological factors influencing patients' outcome
- 32 Downloads
Sixty-five medulloblastomas in infancy and childhood treated from 1965 through 1981 were reviewed, and the correlation between histological findings of medulloblastomas and clinical course of the patients was studied. Thirty-five patients died but the remaining 30 are alive and without clinical evidence of recurrence 5 years or more after surgery. Certain histological features on light microscopic examinations (e.g., pleomorphism of tumor cells, nuclear-cytoplasmic ratio, mitotic index, degree of vascularity and endothelial proliferation) do influence patient outcome with statistical significance (P<0.05). Thirty out of 65 medulloblastomas were examined further, using immunohistochemical methods with glial fibrillary acidic protein (GFAP), neuron specific enolase (NSE), and factor VIII/vW factor (F VIII/vWF). GFAP stain was negative in 20%, NSE stain in 13.3% and F VIII/vWF stain in 16.7% of the medulloblastomas studied. “Desmoplastic” medulloblastomas showed a strong tendency toward positive NSE and GFAP staining in the glomerular portion. There was no correlation between patient outcome and the results of applied immunohistochemical studies. Our data indicate that certain histological features may influence patient outcome, but the degree and pattern of cellular differentiation do not predict outcome.
Key wordsBrain neoplasms Medulloblastoma Immunohistochemistry Glial fibrillary acidic protein Neuron-specific enolase Factor VIII/von Willebrand factor
Unable to display preview. Download preview PDF.
- 3.Bignami A, Schoene WC (1981) Glial fibrillary acidic protein in human brain tumors. In: DeLellis RA (ed) Diagnostic immunohistochemistry. Masson, New York, pp 213–225Google Scholar
- 12.Duffy PE, Graf L, Huang Y, Rapport MM (1979) Glial fibrillary acidic protein in ependymomas and other brain tumors. J Neurol 40:133–146Google Scholar
- 14.Evans AE, Anderson J, Chang C, Jenkin RDT, Kramer S, Schoenfeld D, Wilson C (1979) Adjuvant chemotherapy for medulloblastoma and ependymoma. In: Paoletti P, Walker MD, Butti G, Knerich R (eds) Multidisciplinary aspects of brain tumor therapy. Elsevier/North-Holland, New York, pp 219–222Google Scholar
- 37.Soejima T (1970) Fine structure of medulloblastoma. Gan No Rinsho 61:17–26Google Scholar
- 39.Sternberger LA, Hardy PH Jr, Cuculis JJ, Meyer HG (1970) The unlabelled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 18:315–333CrossRefGoogle Scholar