Journal of Molecular Medicine

, Volume 73, Issue 2, pp 85–88 | Cite as

Graves' disease in HTLV-I carriers

  • H. Kawai
  • K. Yokoi
  • M. Akaike
  • M. Kunishige
  • M. Abe
  • Y. Tanouchi
  • H. Mine
  • Y. Mimura
  • S. Saito
Case Report


Three carriers of human T-lymphotropic virus type I (HTLV-I) with Graves' disease are reported. All three cases were complicated with uveitis, and one also showed chronic arthropathy. Anti-HLTV-I antibody was found in the serum by the particle agglutination method and western blotting, and HTLV-I proviral DNA was detected in peripheral lymphocytes by the polymerase chain reaction and Southern blotting. HTLV-I is a causal agent of adult T-cell leukemia and HTLV-I associated myelopathy/tropical spastic paraparesis, and is believed to be related to the pathogenesis of diseases such as chronic arthropathy, uveitis, chronic bronchoalveolitis, and Sjögren's syndrome. On the other hand, retrovirus infection is considered to cause autoimmune diseases. Thus, the pathogenesis of Graves' disease in the present patients might be associated with HTLV-I infection.

Key words

Human T-lymphotropic virus type I Graves' disease Uveitis Chronic arthropathy Autoimmune thyroidpathy 



Human T-lymphotropic virus type I


adult T-cell leukemia


HTLV-I associated myelopathy


Tropical spastic paraparesis


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • H. Kawai
    • 1
  • K. Yokoi
    • 1
  • M. Akaike
    • 1
  • M. Kunishige
    • 1
  • M. Abe
    • 1
  • Y. Tanouchi
    • 2
  • H. Mine
    • 1
  • Y. Mimura
    • 2
  • S. Saito
    • 1
  1. 1.First Department of Internal MedicineSchool of Medicine, The University of TokushimaTokushimaJapan
  2. 2.Department of OphthalmologySchool of Medicine, The University of TokushimaTokushimaJapan

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