, Volume 98, Issue 5, pp 275–281 | Cite as

Localization of collagen X in human fetal and juvenile articular cartilage and bone

  • A. G. Nerlich
  • T. Kirsch
  • I. Wiest
  • P. Betz
  • K. von der Mark


The tissue localization was analysed of collagen X during human fetal and juvenile articular cartilagebone metamorphosis. This unique collagen type was found in the hypertrophic cartilage zone peri- and extracellularly and in cartilage residues within bone trabeculae. In addition, occasionally a slight intracellular staining reaction was found in prehypertrophic proliferating chondrocytes and in chondrocytes surrounding vascular channels. A slight staining was also seen in the zone of periosteal ossification and occasionally at the transition zone of the perichondrium to resting cartilage. Our data provide evidence that the appearance of collagen X is mainly associated with cartilage hypertrophy, analogous to the reported tissue distribution of this collagen type in animals. In addition, we observed an increased and often “spotty” distribution of collagen X with increasing cartilage “degeneration” associated with the closure of the growth plate. In basal hypertrophic cartilage areas, a co-distribution of collagens II and X was found with very little and “spotty” collagen III. In juvenile cartilage areas around single hypertrophic chondrocytes, co-localization of collagens X and I was also detected.


Articular Cartilage Transition Zone Bone Trabecula Collagen Type Tissue Distribution 
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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • A. G. Nerlich
    • 1
  • T. Kirsch
    • 2
  • I. Wiest
    • 1
  • P. Betz
    • 3
  • K. von der Mark
    • 2
  1. 1.Pathologisches Institut der Universität MünchenMünchen 2Federal Republic of Germany
  2. 2.Max-Planck Arbeitsgruppe für klinische Rheumatologie an der Universität Erlangen-NürnbergErlangenFederal Republic of Germany
  3. 3.Institut für Rechtsmedizin der Universität MünchenMünchen 2Federal Republic of Germany

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