Molecular and General Genetics MGG

, Volume 126, Issue 4, pp 357–366 | Cite as

Induction by manganese of mitochondrial antibiotic resistance mutations in yeast

  • Alexandra Putrament
  • Hanna Baranowska
  • Wieslawa Prazmo


Manganese added to the growth medium of Saccharomyces cerevisiae to a final concentration of 4–8 mM induces not only mitochondrial respiratory-deficient mutations (Fig. 1), but also mitochondrial mutations to chloramphenicol- and erythromycin-resistance (Fig. 1, Tables 1–3). This is the first mutagen shown to be capable of inducing mitochondrial antibiotic resistance mutations in yeast. It is assumed that manganese induces mutations through its interaction with mitochondrial DNA polymerase.


Manganese Final Concentration Growth Medium Saccharomyces Cerevisiae Chloramphenicol 
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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Alexandra Putrament
    • 1
  • Hanna Baranowska
    • 1
  • Wieslawa Prazmo
    • 1
  1. 1.Department of Genetics, Institute of Biochemistry and BiophysicsPolish Academy of SciencesWarsawPoland

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