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Molecular and General Genetics MGG

, Volume 126, Issue 4, pp 325–335 | Cite as

Fertility functions of resistance factors

Mutants of an F-like R factor which do not repress the F factor but remain self-repressed
  • Ibrahim A. -K. Al-Sowaygh
  • William T. Drabble
Article
  • 26 Downloads

Summary

Three mutations (fin-1, fin-3 and fin-4) of the F-like R factor R381 have been recognised in the HfrC strain of Escherichia coli K12. The mutant R factors do not repress F-functions (sensitivity to male-specific phages and chromosome transfer) in the Hfr strain to the same extent as R381 fin+. However, unlike the derepressed R factors described previously, the mutant R factors neither confer sensitivity to male-specific phages on F- strains nor show a high rate of conjugational transfer. Dominance tests in heterodiploid strains with repressor-negative mutants of either R381 or R66 (F-like) indicate that fin-1, fin-3 and fin-4 produce repressors of R. It is concluded that the three mutations result in the production of altered repressors which are active on R but not on F.

Keywords

Escherichia Coli Fertility Function Resistance Factor Conjugational Transfer Dominance Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Ibrahim A. -K. Al-Sowaygh
    • 1
    • 2
  • William T. Drabble
    • 1
  1. 1.Department of Physiology and BiochemistryThe University of SouthamptonSouthamptonUnited Kingdom
  2. 2.Faculty of PharmacyRiyad UniversitySaudi Arabia

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