Molecular and General Genetics MGG

, Volume 132, Issue 1, pp 31–40

Transposition of ampicillin resistance from RP4 to other replicons

  • R. W. Hedges
  • A. E. Jacob
Article

Summary

The ampicillin resistance (β-lactamase) determinant of RP4 can be transposed onto various other replicons genetically unrelated to RP4 including several but not all R factors.

Plasmids which acquire this resistance show an increase in molecular weight. They also acquire the ability to transpose the ampicillin resistance to further replicons.

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • R. W. Hedges
    • 1
  • A. E. Jacob
    • 1
  1. 1.Bacteriology DepartmentRoyal Postgraduate Medical SchoolLondon

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