Analysis of a case of mutagen specificity inNeurospora crassa
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Weak doses of DEB given before or after a moderately high dose act as “booster” for the production of adenine-reversions. Fractionation of a moderate or high dose into a succession of weak ones yields a dose-effect curve that lies above the linear curve expected for additivity of the fractions but below that found after continuous exposure. The results lend support to the view that DEB, in addition to producing potential adenine-reversions in DNA, promotes their realization by its effect on some cellular process or processes, and that this is the cause of the steep dose-response to continuous exposure.
KeywordsFractionation Cellular Process Continuous Exposure Mutagen Specificity Linear Curve
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