Molecular and General Genetics MGG

, Volume 160, Issue 2, pp 195–202

Virulent mutants of temperate phage Mu-1

  • Françoise van Vliet
  • Martine Couturier
  • Lucie Desmet
  • Michel Faelen
  • Ariane Toussaint
Article

Summary

Virulent mutants of phage Mu have been isolated after mutagenesis. The virulent phenotype results from most probably 2 mutations located in the c-A region of the Mu genome.

Vir mutants are trans-dominant; they induce the resident prophage upon infection in broth of any Mu lysogen. They however form plaques only on certain lysogens, that are monolysogenic for a mutant prophage. We further isolated secondary mutations in Mu Vir which suppress the virulent phenotype.

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Françoise van Vliet
    • 1
  • Martine Couturier
    • 1
  • Lucie Desmet
    • 1
  • Michel Faelen
    • 1
  • Ariane Toussaint
    • 1
  1. 1.Department de Biologie MoléculaireUniversité Libre de BruxellesRhode-St-GenèseBelgium
  2. 2.Laboratorium voor GeneticaRijksuniversiteit te GentGentBelgium

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