European Journal of Clinical Pharmacology

, Volume 45, Issue 4, pp 333–336 | Cite as

Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack

  • H. Kiesewetter
  • F. Jung
  • E. M. Jung
  • C. Mrowietz
  • J. Koscielny
  • E. Wenzel
Originals

Summary

A platelet-inhibiting effect is described for garlic. In this double-blind, placebo-controlled study on 60 voluntary subjects with cerebrovascular risk factors and constantly increased platelet aggregation it was demonstrated that the daily ingestion of 800 mg of powdered garlic (in the form of coated tablets) over 4 weeks led to a significant inhibition of the pathologically increased ratio of circulating platelet aggregates and of spontaneous platelet aggregation. The ratio of circulating platelet aggregates decreased by 10.3%, from 1.17±0.08 to 1.05±0.11 (P<0.01), and spontaneous platelet aggregation by 56.3%, from 40.7±23.3 to 17.8±23.2 degrees (P<0.01) during the garlic phase. There were no significant changes in the placebo group. The parallel group comparison (garlic versus placebo) revealed a significantly different ratio of circulating platelet aggregates after 4 weeks of treatment (P<0.05).

After the 4-week wash-out phase the values increased again to 1.19±0.32 and 34.9±28.7°, reaching the initial values (run-in phase prior to the ingestion of garlic). Since garlic is well tolerated it would be worth testing it in a controlled clinical trial for usefulness in preventing disease manifestations associated with platelet aggregation.

Key words

Garlic Platelet aggregation 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • H. Kiesewetter
    • 1
  • F. Jung
    • 1
  • E. M. Jung
    • 1
  • C. Mrowietz
    • 1
  • J. Koscielny
    • 1
  • E. Wenzel
    • 1
  1. 1.Department of Clinical Haemostasiology and Transfusion MedicineUniversity of the SaarlandHomburg/SaarGermany

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