Advertisement

Polymer Bulletin

, Volume 13, Issue 4, pp 293–299 | Cite as

Poly(β-malic acid) : a new polymeric drug-carrier

Evidence for degradation in vitro
  • Christian Braud
  • Claude Bunel
  • Michel Vert
Drug Carriers

Summary

Poly(β-malic acid) is a new synthetic functional polyester of the poly(β-hydroxy-acid)-type whose properties are investigated in regard to possible uses as bioresorbable polyvalent drug-carrier. Degradation of polymer chains in 0.15 N phosphate buffer at pH=7.5 is monitored by aqueous GPC on SEPHADEX gels and by enzymatic titration of ultimate degradation products. It is shown that the rate of degradation obeys first order kinetics at the begining and that poly(β-malic acid) degrades to malic acid at last.

Keywords

Polymer Phosphate Phosphate Buffer Titration Polymer Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. BRAUD, C., BUNEL, C., GARREAU, H. and VERT, M.: Polymer Bull. 9, 198 (1983)Google Scholar
  2. BRAUD, C., BUNEL, C., VERT, M., BOUFFARD, Ph., CLABAUT, M. and DELPECH B.: 28th IUPAC International Symposium on Macromolecules, Amherst, 1982, p384Google Scholar
  3. BRAUD, C. and VERT, M.: ACS Polym. Prept. 24(1), 71 (1983)Google Scholar
  4. BRAUD, C., VERT, M. and LENZ, R.W.: 27th IUPAC International Symposium on Macromolecules, Strasbourg, 1981, p1086Google Scholar
  5. BUNEL, C. and VERT, M.: 24th IUPAC Microsymposium: “Copolymers: Structure and Solution Properties”, Prague, 1983, pP52–1Google Scholar
  6. GEBELEIN, C.G.: Polymer News 4, 163 (1978)Google Scholar
  7. JOHNS, D.B.: Ph.D Thesis, Univ. of Massachusetts, 1983Google Scholar
  8. KOPECEK, J.: Polym. in Med. 7, 191 (1977)Google Scholar
  9. KRAMER, P.A. in “Optimization of Drug Delivery”, Eds. BUNDGAARD, H., BAGGER-HANSEN, A., KOFOD, H., Munksgaard Copenhagen, 1982, p239Google Scholar
  10. MONNERIE, L. and NEEL, J.: J. Chim. Phys. 62, 53 (1965a)Google Scholar
  11. MONNERIE, L. and NEEL, J.: J. Chim. Phys. 62, 510 (1965b)Google Scholar
  12. OTTENBRITE, R.M. in “Anionic Polymeric Drugs”, Eds. DONARUMA, L.G., OTTENBRITE, R.M., VOGL, O., WILEY & Sons, New York 1980, p21Google Scholar
  13. RINGDORF, H.: J. Polym. Sci., Polym. Symp. 51, 135 (1975)Google Scholar
  14. VERT, M. and LENZ, R.W.: ACS Polym. Prept. 20(1), 608 (1979)Google Scholar
  15. VERT, M. and LENZ, R.W.: US Patent n∘4, 265, 247 July 1, 1981Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Christian Braud
    • 1
  • Claude Bunel
    • 1
  • Michel Vert
    • 1
  1. 1.University of Rouen, UA CNRS 500, LSM INSCIRMont-Saint-AignanFrance

Personalised recommendations