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Diabetologia

, Volume 18, Issue 6, pp 501–505 | Cite as

Renal hypertrophy in experimental diabetes

A morphometric study
  • K. Seyer-Hansen
  • Joan Hansen
  • H. J. G. Gundersen
Originals

Summary

Renal hypertrophy in rats with streptozotocin diabetes or after unilateral nephrectomy was studied by sterological techniques. — After 4 days of diabetes total glomerular volume had increased by 30%, and after 47 days by 43%. Glomerular growth was more pronounced than whole kidney growth during the first 4 days, but subsequently whole kidney growth exceeded glomerular growth. In control rats glomerular volume was 4.9% of total kidney volume; after 4 days of diabetes it was 5.4% and after 47 days 4.1%. — Proximal tubule length increased from 366 m/kidney in control rats to 447 m/kidney after 47 days of diabetes; tubular luminal diameter increased from 26.8 μm to 31.4 μm in the same rats. Tubular length and luminal diameter were, however, not increased after 4 days of diabetes. — In unilaterally nephrectomised rats there was no early rapid glomerular growth. Glomerular fractional volume was 4.9% in controls, 4.4% at four days, and 4.2% at 24 days after nephrectomy. — The results indicate a disturbed glomerulo-tubular balance in the early phases of diabetic renal hypertrophy.

Key words

Diabetes glomerulus hypertrophy kidney morphometry nephrectomy proximal tubule rats stereology 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • K. Seyer-Hansen
    • 1
    • 2
  • Joan Hansen
    • 1
    • 2
  • H. J. G. Gundersen
    • 1
    • 2
  1. 1.Second Clinic of Internal Medicine, KommunehospitaletÅrhusDenmark
  2. 2.Institute of Experimental Clinical ResearchÅrhus UniversityÅrhusDenmark

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