Molecular and General Genetics MGG

, Volume 220, Issue 1, pp 154–156 | Cite as

The Salmonella typhimurium glycine cleavage enzyme system

  • George V. Stauffer
  • Lorraine T. Stauffer
  • Michael D. Plamann
Short Communications


A glycine cleavage enzyme system, inducible by glycine, has been demonstrated in Salmonella typhimurium. The induced enzyme levels, however, are only about 20% of the induced levels found in Escherichia coli. Starting with a serine auxotroph, mutants were isolated that grow with a serine supplement, but not with a glycine supplement. Three independently isolated mutants have reduced or nondetectable glycine cleavage enzyme levels. The new mutations, designated gcv, were mapped between the serA and lys genes at 62.5 min on the S. typhimurium chromosome.

Key words

gcv Glycine cleavage Regulation Mutations 





glycine cleavage


glucose minimal

L agar

Luria agar


Luria broth




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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • George V. Stauffer
    • 1
  • Lorraine T. Stauffer
    • 1
  • Michael D. Plamann
    • 1
  1. 1.Department of MicrobiologyUniversity of IowaIowa CityUSA

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