Über die humorale Beeinflussung des experimentellen Lathyrismus

Summary

Experiments on albino rats indicate that various humoral agencies can markedly influence the manifestations of skeletal lathyrism that are normally produced by aminoacetonitrile (AAN).

Thyroparathyroidectomy moderately enhances the skeletal lathyrism thus produced. This effect is not significantly altered by mere maintenance doses of thyroxine, but intensive overdosage with this hormone totally prevents the bone changes normally elicited by AAN.

An amount of ACTH, that more than doubles the weight of the adrenals and causes pronouced thymus atrophy, also inhibits the effect of AAN, but fails to prevent it completely. This is all the more noteworthy because comparatively small doses of cortisol can totally prevent such bone lesions.

Extensive partial hepatectomy greatly increases the effect of AAN upon the bones.