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European Journal of Nuclear Medicine

, Volume 12, Supplement 1, pp S62–S65 | Cite as

Metabolism and blood flow as new markers of myocardial viability in the evolution of myocardial infarction

  • M. Schwaiger
Article

Abstract

Animal studies have shown that increased regional 18F-deoxyglucose (FDG) uptake as demonstrated by positron emission tomography (PET) in ischemic and reperfused myocardium reflects reversible tissue injury. Therefore, we studied patients with acute myocardial infarction to define the extent and severity of injury. Left ventricular segments with reduced blood flow and metabolism, as demonstrated by matching defects of flow and FDG uptake, revealed irreversible injury as evidenced by lack of functional recovery. In contrast, segments with reduced flow but maintained FDG uptake showed variable functional outcome with improvement of the average wall motion score. Thus, PET may be useful in identifying myocardium at risk which may benefit from therapeutic interventions.

Key words

Myocardial infarction Positron emission tomorgraphy 18F-Deoxyglucose 13N-Ammonia 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • M. Schwaiger
    • 1
    • 2
  1. 1.Division of Nuclear Medicine and Biophysics Department of Radiological Sciences, UCLA School of MedicineUniversity of CaliforniaLos AngelesUSA
  2. 2.Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental SciencesUniversity of CaliforniaLos AngelesUSA

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