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Urological Research

, Volume 11, Issue 3, pp 105–109 | Cite as

A comparative study of several agents alone and combined in protection of the rodent kidney from warm ischaemia: Methylprednisolone, propranolol, furosemide, mannitol, and adenosine triphosphate-magnesium chloride

  • G. Aydin
  • S. E. Okiye
  • H. Zincke
Originals

Summary

The effect of 60 min of in situ warm ischaemia (37°C) on renal function was investigated in the rat model. In addition, the effect of pretreatment with intravenously administered furosemide, mannitol, propranolol, methylprednisolone, and adenosine triphosphate-magnesium chloride (ATP-MgCl2), singly or in combination, was studied. The ischaemic kidney was effectively protected by the administration of methylprednisolone alone but not by furosemide, mannitol, ATP-MgCl2, or propranolol singly or in combination. These results demonstrate that rat kidneys subjected to 60 min of warm ischaemia can be safely protected with methylprednisolone pretreatment (3mg/100 g of body weight) 30 min before warm ischaemia.

Key words

Ischaemic kidney Kidney protection Methylprednisolone Renal function 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • G. Aydin
    • 1
  • S. E. Okiye
    • 1
  • H. Zincke
    • 1
  1. 1.Department of UrologyMayo Clinic and Mayo FoundationRochesterUSA

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