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Cancer Chemotherapy and Pharmacology

, Volume 1, Issue 4, pp 229–231 | Cite as

Pharmacokinetics of intravenous cyclophosphamide in man, estimated by gas-liquid chromatography

  • F. D. Juma
  • H. J. Rogers
  • J. R. Trounce
  • I. D. Bradbrook
Original Articles Pharmacokinetics of Cyclophosphamide

Summary

A simple gas chromatographic assay utilising alkali flame ionisation detection is described for the estimation of cyclophosphamide as its trifluoroacetate derivative from plasma. Examination of five patients following intravenous cyclophosphamide gave values of 8.9 h (SD 2.7) for the half-life and 0.061 liters/h/kg (SD 0.011) for whole-body clearance of the drug.

Keywords

Cancer Research Cyclophosphamide Ionisation Detection Flame Ionisation Detection Trifluoroacetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • F. D. Juma
    • 1
  • H. J. Rogers
    • 1
  • J. R. Trounce
    • 1
  • I. D. Bradbrook
    • 2
  1. 1.Department of Clinical PharmacologyGuy's Hospital, Medical SchoolLondonEngland
  2. 2.Department of Forensic MedicineGuy's Hospital, Medical SchoolLondonEngland

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