Urological Research

, Volume 9, Issue 2, pp 99–103 | Cite as

The effect of pre-existing bacteriuria on bladder resistance to superinfection in the rabbit

  • Philip M. Hanno
  • Robert Fritz
  • Alan J. Wein
  • S. Grant Mulholland


Pre-existing bacteriuria of 2 to 3 weeks' duration in the rabbit had no effect on either the histological integrity of the sialomucin layer (anti-adherence factor) of the bladder mucosa or the protective effect of this layer against super-infection.

Key words

Urinary tract infection Super-infection Anti-adherence factor Sialomucin layer 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Corriere, J. N., Jr., Lipshultz, L. I., Wallach, E. E., Garcia, C. R., Murphy, J. J.: Bacteriuria in young women, effect of estrogen, progestogen, and estrogen-progestogen combination. Urology 2, 539 (1973)Google Scholar
  2. 2.
    Evans, D. A., Hennekens, C. H., Miao, L., Laughlin, L. W., Chapman, W. G., Rosner, B., Taylor, J. O., Kass, E. H.: Oral-contraceptive use and bacteriuria in a community-based study. New England Journal of Medicine 299, 536 (1978)Google Scholar
  3. 3.
    Hanno, P. M., Parsons, L. L., Shrom, S. H., Fritz, R., Mulholland, S. G.: The protective effect of heparin in experimental bladder infection. Journal of Surgical Research 25, 324 (1978)Google Scholar
  4. 4.
    Hanno, P. M., Fritz, R., Wein, A. J., Mulholland, S. G.: Heparin as antibacterial agent in rabbit bladder. Urology 12, 411 (1978)Google Scholar
  5. 5.
    Hinman, F., Cox, C. E.: The voiding vesical defense mechanism: The mathematical effect of residual urine, voiding interval, and volume on bacteriuria. Journal of Urology 96, 491 (1966)Google Scholar
  6. 6.
    Kass, E. H., Savage, W. D., Santamarina, B. A. G.: The significance of bacteriuria in preventive medicine. In: Progress in pyelonephritis. Kass, E. H. (ed.), Philadelphia: F. A. Davis & Co. 1964Google Scholar
  7. 7.
    Lapides, J.: Urinary infection. In: Fundamentals of urology. Lapides, J. (ed.), p. 276. Philadelphia: W. B. Saunders Co. 1976Google Scholar
  8. 8.
    Lloyd-Davies, R. W., Hayes, T. L., Hinman, F.: Urothelial microcontour. III. Mucosal alteration by infection. Journal of Urology 106, 81 (1971)Google Scholar
  9. 9.
    Mackintosh, I. P., Hammond, B. J., Watson, B. W., O'Grady, F.: Theory of hydrokinetic clearance of bacteria from the urinary bladder. 1. Effect of bacterial growth rate. Investigative Urology 12, 468 (1975)Google Scholar
  10. 10.
    Monis, B., Dorfman, H. D.: Some histochemical observations on transitional epithelium of man. Journal of Histochemistry and Cytochemistry. 15, 475 (1967)Google Scholar
  11. 11.
    Monis, B., Dorfman, H. D.: Histochemical localization of sialic acid containing mucins in transitional epithelium of urinary tract of man in normal and pathological conditions. American Journal of Pathology 46, 38a (1965)Google Scholar
  12. 12.
    Parsons, C. L., Greenspan, C., Mulholland, S. G.: The primary antibacterial defense mechanism of the bladder. Investigative Urology 13, 72 (1975)Google Scholar
  13. 13.
    Parsons, C. L., Greenspan, C., Moore, S. W., Mulholland, S. G.: Role of surface mucin in primary antibacterial defense of bladder. Urology 9, 48 (1977)Google Scholar
  14. 14.
    Parsons, C. L., Mulholland, S. G.: Bladder surface mucin — its antibacterial effect against various bacterial species. American Journal of Pathology 93, 423 (1978)Google Scholar
  15. 15.
    Shrom, S. H., Parsons, C. L., Mulholland, S. G.: The role of urothelial surface mucoprotein in intrinsic bladder defense. Urology 9, 526 (1977)Google Scholar
  16. 16.
    Uehling, D. T., Mizutani, K., Balish, E.: Effect of immunization on bacterial adherence to urothelium. Urology 16, 145 (1978)Google Scholar
  17. 17.
    Zahran, M. M., Kamel, M., Mooro, H., Osman, M. I., Fayad, M., Youssef, A. F.: Effects of contraceptive pills and intrauterine devices on urinary bladder. Urology 8, 567 (1976)Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Philip M. Hanno
    • 1
    • 2
  • Robert Fritz
    • 1
    • 2
  • Alan J. Wein
    • 1
    • 2
  • S. Grant Mulholland
    • 1
    • 2
  1. 1.Division of Urology, Department of SurgeryUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.the Philadelphia Veterans Administration HospitalPhiladelphiaUSA

Personalised recommendations