Cancer Chemotherapy and Pharmacology

, Volume 4, Issue 4, pp 267–269 | Cite as

Comparative pharmacokinetics of medroxyprogesterone acetate administered by oral and intramuscular routes

  • M. Salimtschik
  • H. T. Mouridsen
  • J. Loeber
  • E. Johansson
Original Articles Medroxyprogesterone Pharmacokinetics


The present study was undertaken to elucidate (1) the relationship between plasma concentration of medroxyprogesterone acetate (MPA; Clinovir) administered by the PO and the IM routes; and (2) the relationship between dose and plasma concentration of MPA.

Nineteen patients entered the study. In each patient the plasma concentration was monitored after a single PO and IM administration of MPA at the following dose levels: 100 mg (5 patients), 400 mg (5 patients), 800 mg (5 patients) and 1,200 mg (4 patients). The time interval between PO and the IM administration was 1 week.

The results show (1) a very large interindividual variation in plasma concentration; (2) increasing plasma concentration with both PO and IM dose; (3) after the IM administration plasma levels are steady or increase slightly within the test period; (4) after the oral administration the concentration increases rapidly to reach a peak before 2–7 h and subsequently decreases again, peak concentrations being 2–10 times higher than after IM administration; and (5) within the test periods the plasma concentration x time (0–168 h) is comparable with the two methods of administration.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cornette JC, Kirton KT, Duncan GW (1971) Measurement of medroxyprogesteroneacetate (Provera) by radioimmunoassay. J Clin Endocrinol 33: 459Google Scholar
  2. 2.
    De Lena M, Brambilla C, Valagussa P, Bonadonna G (1979) High-dose medroxyprogesterone acetate in breast cancer resistant to endocrine and cytotoxic therapy. Cancer Chemother Pharmacol 2: 175Google Scholar
  3. 3.
    Edquist LE, Johansson EDP (1972) Radioimmunoassay of estrone and estradiol in human and bovine peripheral plasma. Acta Endocrinol (Kbh) 71: 716Google Scholar
  4. 4.
    Goldenberg IS (1969) Clinical trials of testolactone, medroxyprogesterone-acetate and oxylone acetate in advanced female mammary cancer. A report of the Cooperative Breast Cancer Group. Cancer 23: 109Google Scholar
  5. 5.
    Klaasen DJ, Rapp EF, Hirte WE (1976) Response to medroxyprogesterone acetate (NSC-26386) as secondary hormone therapy for metastatic breast cancer in postmenopausal women. Cancer Treat Rep 60: 251Google Scholar
  6. 6.
    Mattsson W (1978) High dose medroxyprogesterone acetate treatment in advanced mammary carcinoma. A phase-II investigation. Acta Radiol Oncol 17: 387Google Scholar
  7. 7.
    Muggia FM, Cassileth PA, Ochoa M Jr, Flatow FA, Gellhorn A, Hyman GA (1968) Treatment of breast cancer with medroxyprogesterne-acetate. Ann Intern Med 68: 328Google Scholar
  8. 8.
    Pannuti F, Martoni A, Lenaz GR, Piana E, Nanni P (1978) A possible new approach to the treatment of metastatic breast cancer: massive doses on medroxyprogesterone acetate. Cancer Treat Rep 62: 499Google Scholar
  9. 9.
    Robustelli Della Cuna G, Calciata A, Strada MRB, Bumma C, Campio L (1978) High dose medroxyprogesterone-acetate (MPA) treatment in metastatic carcinoma of the breast: a dose-response evaluation. Tumori 64: 143Google Scholar
  10. 10.
    Segaloff A, Cunningham M, Rice BF, Weeth JB (1967) Hormonal therapy in cancer of the breast. XXIV. Effect of corticosterone or medroxyprogesterone acetate on clinical course and hormonal excretion. Cancer 20: 1673Google Scholar
  11. 11.
    Stoll A (1967) Progestin therapy of breast cancer: comparison of agents. Br Med J 3: 338Google Scholar
  12. 12.
    Victor A, Johansson DB (1976) Pharmacokinetic observations on medroxyprogesteroneacetate administered orally and intravaginally. Contraception 14: 319Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • M. Salimtschik
    • 1
  • H. T. Mouridsen
    • 1
  • J. Loeber
    • 1
  • E. Johansson
    • 2
  1. 1.Department RAFinsen InstituteCopenhagen ØDenmark
  2. 2.Department of Obstetrics and GynaecologyUniversity HospitalUppsalaSweden

Personalised recommendations