Chemotherapy in the management of invasive bladder cancer
A review
General Review Bladder Cancer
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Summary
In this review of the management of invasive carcinoma of the bladder the results of primary and systemic therapies are evaluated in the light of the natural history of the disease.
The clinical and pathological causes of treatment failure are assessed in an attempt to identify new approaches that may be used in the future management of patients with bladder cancer.
To improve survival in this disease requires different approaches to both the control of local disease and the early control of metastatic disease.
Keywords
Carcinoma Cancer Research Natural History Bladder Cancer Metastatic Disease
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
- 1.Altman, C. C., McCague, N. J., Ripepi, A. C., Cardozo, M.: The use of methotrexate in advanced carcinoma of the bladder. J. Urol. 108, 271 (1972)Google Scholar
- 2.Ansfield, F.: Treatment of tumours of the urinary tract. In: Chemotherapy of malignant neoplasms. Ansfield, F. (ed.), pp. 288–290. Springfield, Ill.: Thomas 1973Google Scholar
- 3.Barnes, R. W.: Endoscopic surgical treatment of bladder tumours. Urol. Digest. 6, 13 (1967)Google Scholar
- 4.Bloom, H. J. G. Treatment of carcinoma of the bladder. A symposium. Radiology 33, 471 (1960)Google Scholar
- 5.Bloom, H. J. G.: Radiotherapy of bladder tumours. Oncology 3, 234–250 (1970)Google Scholar
- 6.Bonadonna, G., Monfardini, S., DeLena, M., Fossati-Bellani, F., Baretta, G.: Clinical trials with adriamycin — Results of three years study. In: International Symposium on Adriamycin. Carter, S. K., DiMarco, A., Chione, M. (eds.), pp. 139–152. New York: Springer 1972Google Scholar
- 7.Brady, L. W., Gislason, G. J.: The management of carcinoma of the bladder using supervoltage modalities. Am. J. Roentgenol. 89, 150 (1963)Google Scholar
- 8.Brice, M., Marshall, V. F., Green, J. L., Whitmore, W. F.: Simple total cystectomy for carcinoma of the urinary bladder. One hundred and fifty-six cases five years later. Cancer 9, 576 (1956)Google Scholar
- 9.Bufield, G. D.: Intravenous methotrexate in the treatment of advanced bladder cancer. Br. J. Urol. 44, 121 (1972)Google Scholar
- 10.Burn, J. I.: Intra-arterial infusion in malignant disease of the pelvis. In: Second symposium on methotrexate in the treatment of cancer. P. M. Worrall, H. J. Espiner (eds.), pp. 58–73. Bristol: Wright 1966Google Scholar
- 11.Bush, H.: Adjuvant chemotherapy. An approach to the management of malignant disease. Br. J. Hosp. Med. (in press, 1979)Google Scholar
- 12.Caldwell, W. C., Bagshaw, M. A., Kaplan, H. S.: Efficacy of linear accelerator X-ray therapy on cancer of the bladder. J. Urol. 97, 294 (1967)Google Scholar
- 13.Carter, S. K., Wasserman, T. H.: The chemotherapy of urologic cancer. Cancer 36, 729 (1975)Google Scholar
- 14.Collier, D., Soloway, M. S.: Doxorubicin hydrochloride, cyclophosphamide and 5-fluorouracil combination in advanced prostate and transitional cell carcinoma. Urology 8, 459 (1976)Google Scholar
- 15.Cordonnier, J. J.: Value of cystectomy in the management of carcinoma of the bladder. Trans. Am. Assoc. Genitourin. Surg. 48, 197 (1956)Google Scholar
- 16.Cox, R.: Treatment of carcinoma of the bladder by 2 MeV X-rays. Br. J. Radiol. 33, 480 (1960)Google Scholar
- 17.Crigler, C. M., Miller, L. S., Gunn, G. A., Schilloci, H. G.: Radiotherapy for carcinoma of the bladder. J. Urol. 96, 55 (1966)Google Scholar
- 18.Cross, R. J., Glashan, R. W., Humphrey, C. S., Robertson, M. R. G., Smith, P. H., Williams, R. E.: Treatment of advanced bladder cancer with adriamycin and 5-fluorouracil. Br. J. Urol. 48, 609 (1976)Google Scholar
- 19.DeKernion, J. B.: The chemotherapy of advanced bladder carcinoma. Cancer Res. 37, 2771 (1977)Google Scholar
- 20.DeVita, V. T., Young, R. C., Canellos, G. P.: Combination Versus Single-Agent Chemotherapy: Review of basis for selection of drug treatment of cancer. Cancer 35, 98 (1975)Google Scholar
- 21.Dick, D. A. L.: Carcinoma of the bladder treated by external irradiation. Br. J. Urol. 34, 340 (1962)Google Scholar
- 22.Early, K., Elias, E. G., Mittleman, A, Albert, D., Murphy, G. P.: Mitomycin C in the treatment of metastatic transitional cell carcinoma of the urinary bladder. Cancer 31, 1150 (1973)Google Scholar
- 23.Edland, R. W., Wear, J. B., Ansfield, F. J.: Advanced cancer of the urinary bladder. An analysis of the results of radiotherapy alone versus radiotherapy and concomitant 5-fluorouracil. A prospective randomised study of 36 cases. Am. J. Roentgenol. 108, 124 (1970)Google Scholar
- 24.Edsmyr, F., Jacobson, F., Dahl, O., Walstam, R.: Cobalt 60 teletherapy of carcinoma of the bladder. Acta Radiol. Ther. 6, 81 (1967)Google Scholar
- 25.European Organisation for Research on the Treatment of Cancer. Co-operative Group for Leukaemias and Haematosarcomas: Clinical screening of epidophyllotoxin (VM26) in malignant lymphomas and soid tumours. Br. Med. J. 1972 2, 744Google Scholar
- 26.Field, J.: 5-Fluorouracil treatment of advanced cancer in ambulatory patients. Cancer Chemother. Rep. 33, 45 (1963)Google Scholar
- 27.Flocks, R. H.: Treatment of carcinoma of the bladder. JAMA 145, 295 (1951)Google Scholar
- 28.Fox, M.: The effect of cyclophosphamide on some urinary tract tumours. Br. J. Urol. 37, 399 (1965)Google Scholar
- 29.Frei, E., Luce, J. K., Middleman, E.: In: Clinical trials of adriamycin. International Symposium on Adriamycin. Carter, S. K. et al. (eds.), pp. 153–164. Berlin, Heidelberg, New York: Springer 1972Google Scholar
- 30.Friedman, M.: Supervoltage (2MV) rotation irradiation of cancer of the bladder. Radiology 73, 191 (1959)Google Scholar
- 31.Gerarty, J. T.: Treatment of malignant diseases of prostate and bladder. J. Urol. 7, 33 (1922)Google Scholar
- 32.Glenn, J., Hunt, L., Lathem, J.: Chemotherapy of bladder cancer with 5-fluorouracil. Cancer Chemother. Res. 27, 67 (1963)Google Scholar
- 33.Hall, R. R., Bloom, H. J. G., Freeman, J. E., Nawrocki, A., Wallace, D. M.: Methotrexate treatment for advanced bladder cancer. Br. J. Urol. 46, 431 (1974)Google Scholar
- 34.Henderson, E. S., Samaha, R. J.: Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies. Cancer Res. 29, 2272 (1969)Google Scholar
- 35.Herring, H. T.: The treatment of vesical papilloma by injections. (silver nitrate). Br. Med. J. 1903 2, 539Google Scholar
- 36.Holland, J. F., Scharlau, C., Gailani, S., Krant, M. J., Olson, K. B., Horton, J., Shnider, B. I., Lynch, J. J., Owens, A., Carbone, P. P., Colby, J., Grob, D., Miller, S. P., Hall, T. C.: Vincristine treatment of advanced cancer. A co-operative study of 392 cases. Cancer Res. 33, 1258 (1973)Google Scholar
- 37.Ishida, N.: In: Antitumour antibiotics. Symposium 81. 10th International Congress Antimicrobial and Anticancer Chemotherapy. Zurich, 1977Google Scholar
- 38.Jack, E. A.: Improved results of irradiation for carcinoma of the bladder. J. Urol. 102, 330 (1969)Google Scholar
- 39.Jacobs, E. M., Reeves, W. J., Wood, D. A., Pugh, R., Brounwald, J., Bateman, J. R.: Treatment of cancer with weekly intravenous 5-fluorouracil. Cancer 27, 1302 (1971)Google Scholar
- 40.Jewett, H. J.: The diagnosis and treatment of carcinoma of the bladder. Penn. Med. J. 60, 473 (1957)Google Scholar
- 41.Jewett, H. J.: Cancer of the bladder. Diagnosis and staging. Cancer 32, 1072 (1973)Google Scholar
- 42.Jewett, H. J., Strong, G. H.: Infiltrating carcinoma of the bladder. J. Urol. 55, 366 (1946)Google Scholar
- 43.Jewett, H. J., King, L. R., Shelley, W. M.: A study of 365 cases of infiltrating bladder cancer: Relation of certain pathological characteristics to prognosis after extirpation. J. Urol. 92, 668 (1964)Google Scholar
- 44.Johnson, J. E., Knessler, K. E., Karminsky, S., Jing, B. S., Wallace, S.: Lymphangiography as an aid in staging bladder cancer. South. Med. J. 69, 28 (1976)Google Scholar
- 45.Kaufman, J. J.: Treatment of carcinoma of the bladder with combined radiotherapy, chemotherapy and surgery. Arch. Surg. 99, 477 (1969)Google Scholar
- 46.Kaufman, J. J.: Adjunctive radiotherapy in the treatment of invasive carcinoma of the bladder. In: Current controversies in urologic management. R. Scott (ed.), pp. 60–65. Philadelphia: Saunders 1972Google Scholar
- 47.Kurrohara, S. S., Rubin, P., Silou, N.: Analysis in depth of bladder cancer treated by supervoltage therapy. Am. J. Roentgenol. 95, 458 (1965)Google Scholar
- 48.Lang, E. K.: The roentgenographic assessment of bladder tumours. A comparison of the diagnostic accuracy of roentgenographic techniques. Cancer 23, 717 (1969)Google Scholar
- 49.MacKenzie, A. R., Whitmore, W. F., Nickson, J. J.: Supervoltage X-ray therapy of bladder cancer. Cancer 18, 1255 (1965)Google Scholar
- 50.Martin, D. S.: Experimental design for chemotherapeutic cure of spontaneous mammary mouse carcinoma. Proc. Am. Assoc. Cancer Res. 3, 248 (1961)Google Scholar
- 51.Martin, D. S., Fugman, R. A.: Clinical implications of the inter-relationship of tumour size and chemotherapeutic response. Ann. Surg. 151, 87 (1960)Google Scholar
- 52.Merrin, C., Cartegena, R., Wajsman, Z., Baum Gardner, C., Murphy, G. P.: Chemotherapy of bladder cancer with Cytoxan and adriamycin. J. Urol. 114, 884 (1975)Google Scholar
- 53.Miller, L. S.: Bladder Cancer. Superiority of preoperative irradiation and cystectomy in clinical stages B2 and C. Cancer 39, 973 (1977)Google Scholar
- 54.Miller, L. S., Johnson, D. E.: Megavoltage irradiation for bladder cancer, alone, pre-operative or post-operative. In: 7th National Cancer Conference Proceedings, pp. 771 ff. Lippincott 1972Google Scholar
- 55.Milner, W. A.: The role of conservative surgery in the treatment of bladder tumours. Br. J. Urol. 26, 375 (1954)Google Scholar
- 56.Moore, G., Bross, I. D., Ausman, R., Nadler, S., Jones, R., Slack, N., Reim, A.: Effects of 5-fluorouracil in 389 patients with cancer. Cancer Chemother. Rep. 27, 67 (1963)Google Scholar
- 57.Moore, M. R. R., Newton, K. A.: Palliation of malignant pelvic disease by intra-aortic injection of nitrogen mustard or ethoglucid. Cancer Chemother. Rep. 41, 19 (1964)Google Scholar
- 58.Morrison, R. J.: Carcinoma of the bladder. Its treatment by supervoltage X-ray therapy. Clin. Radiol. 11, 125 (1960)Google Scholar
- 59.Munro, A. I.: The results of using radioactive gold grains in the treatment of bladder growths. Br. J. Urol. 36, 541 (1964)Google Scholar
- 60.Nevin, J. E., Melnick, I., Baggerly, J. T., Hoffman, A., Landes, R. R., Easley, C.: The continuous arterial infusion of 5-fluorouracil as a therapeutic adjunct. Cancer 31, 138 (1973)Google Scholar
- 61.Nichols, J. A., Marshall, B. F.: Treatment of histologically benign papilloma of the urinary bladder by local excision and a fulguration. Cancer 9, 24 (1956)Google Scholar
- 62.Ogata, J., Migita, N., Nakamura, T.: Treatment of carcinoma of the bladder by infusion of the anticancer agent mitomycin C via the internal iliac artery. J. Urol. 110, 667 (1973)Google Scholar
- 63.Omura, J., Migita, N., Nakamura, T.: Clinical and pathological studies on cancer of the urinary bladder with anticancer drugs. Gann Symp. Monogr. 18, 52–82 (1962)Google Scholar
- 64.Paterson, R., Pointon, R. S. P.: Manchester staging of carcinoma of the bladder. In: The treatment of malignant diseases by radiotherapy. pp 369 ff. London: Edward Arnold 1963Google Scholar
- 65.Pavone-Macaluso, M.: Chemotherapy of vesical and prostatic tumours. Br. J. Urol. 43, 701 (1971)Google Scholar
- 66.Pointon, R. S.: An analysis of the results of treatment on carcinoma of the bladder by radical (three weeks) megavoltage (4MV) X-ray therapy. In: International Bladder Cancer Conference. Leeds, UICC (1971)Google Scholar
- 67.Poole-Wilson, D. S.: The treatment of malignant tumours of the bladder by irradiation therapy. Br. J. Urol. 26, 326 (1954)Google Scholar
- 68.Prout, G. R.: The surgical management of bladder carcinoma. Urol. Clin. North Am. 3, 149 (1976)Google Scholar
- 69.Prout, G. R., Bross, I. D. J., Slack, N. H., Ansmann, R. K.: Carcinoma of the bladder: 5-FU and the critical role of a placebo. Cancer 22, 926 (1968)Google Scholar
- 70.Prout, G. R., Slack, N. H., Bross, I. D. J.: Irradiation and 5-fluorouracil in the management of invasive bladder carcinoma. A co-operative group report after 4 years. J. Urol. 104, 116 (1970)Google Scholar
- 71.Prout, G. R., Slack, N. H., Bross, I. D. J.: Preoperative irradiation and cystectomy for bladder carcinoma. Results in a selected population. 7th National Cancer Conference Proceedings. Lippincott. pp. 783–793 (1973)Google Scholar
- 72.Pryor, J. P.: Factors influencing the survival of patients with transitional cell tumours of the bladder. Br. J. Urol. 45, 586 (1973)Google Scholar
- 73.Riches, E.: Choice of treatment in carcinoma of bladder. J. Urol. 84, 472 (1960)Google Scholar
- 74.Roosa, R., Weaver, C. F., Delameter, E. D.: Importance of transplant size in chemotherapeutic assay with the use of the Gardner lymphosarcoma. Proc. Am. Assoc. Cancer Res. 3, 243 (1957)Google Scholar
- 75.Rubin, P.: The impact of supervoltage irradiation on the treatment of bladder cancer. J. Urol. 86, 82 (1961)Google Scholar
- 76.Scott, R., Koff, W. J., Hudgins, P. T., McCullough, D.: Preoperative irradiation in the surgical treatment of transitional cell carcinoma of the bladder. A preliminary report based on 12 years experience. J. Urol. 109, 405 (1973)Google Scholar
- 77.Semple, J. E.: Papillomata of the bladder treated with podophyllin, Br. Med. J. 1948 1, 1235Google Scholar
- 78.Shnider, I., Gold, G., Hall, T., Dederick, M., Nevinny, H. B., Potty, K., Lasagna, L., Owens, A. H., Hreschyshyn, H., Selawry, O., Holland, J. F., Jones, R., Colsky, J., Franzino, A., Zubrud, C., Frei, E., Brindley, C.: Preliminary studies with cyclophosphamide. Cancer Chemother. Rep. 8, 106 (1960)Google Scholar
- 79.Skinner, D. G.: Current state of classification and staging in bladder cancer. Cancer Res. 37, 2838 (1977)Google Scholar
- 80.Slavik, M.: Adriamycin activity in genito-urinary and gynaecological malignancy. In: Fifty New Drug Seminar. National Cancer Institute 1974Google Scholar
- 81.Soloway, M. S.: Single and combination chemotherapy for primary murine bladder cancer. Cancer 36, 333 (1975)Google Scholar
- 82.Soloway, M. S., DeKernion, J. B., Rose, J. D., Persky, L.: Effect of chemotherapeutic agents on bladder cancer. A new animal model. Surg. Forum. 13, 542 (1973)Google Scholar
- 83.Stein, J. T., Kaufman, J. T.: The treatment of carcinoma of the bladder with special reference to the use of preoperative radiation therapy combined with 5-fluorouracil. Am. J. Roentgenol. 102, 519 (1968)Google Scholar
- 84.Stone, J. H., Hodges, C. V.: Radical cystectomy for invasive bladder cancer. J. Urol. 96, 207 (1966)Google Scholar
- 85.Sullivan, R. D.: Intra-arterial methotrexate therapy. The dose, duration and route of administration. Studies of methotrexate in clinical cancer chemotherapy. In: First Symposium on the Treatment of Cancer. Porter, R., Wiltshaw, E. (eds.), pp. 50–55. Bristol: Wright 1962Google Scholar
- 86.Turner, A. G., Hendry, W. F., MacDonald, J. S., Wallace, J. M.: The value of lymphography in the management of bladder cancer. Br. J. Urol. 48, 579 (1976)Google Scholar
- 87.Turner, A. G., Hendry, W. F., Williams, G. B., Bloom, H. J. G.: The treatment of advanced bladder cancer with methotrexate. Br. J. Urol. 49, 673–678 (1977)Google Scholar
- 88.Van Der Werf-Messing, B.: Treatment of carcinoma of the bladder with radium. Clin. Radiol. 15, 16 (1964)Google Scholar
- 89.Van der Werf-Messing, B.: Telecobalt treatment of carcinoma of the bladder. Clin. Radiol. 16, 165 (1965)Google Scholar
- 90.Van der Werf-Messing, B.: Carcinoma of the bladder treated with suprapubic radium implants. Eur. J. Cancer 5, 277 (1969)Google Scholar
- 91.Van der Werf-Messing, B.: Careinoma of the bladder treated by preoperative irradiation followed by cystectomy. Eur. J. Cancer 7, 467 (1971)Google Scholar
- 92.Wajsman, Z., Baumgartner, G., Murphy, G. P., Merrin, C.: Lymphangiography in tumours of the kidney, bladder and testis. J. Urol. 114, 712 (1975)Google Scholar
- 93.Wallace, D. M., Bloom, H. J. G.: The management of deeply infiltrating (T3) bladder carcinoma. Br. J. Urol. 48, 587 (1976)Google Scholar
- 94.Weinstein, S., Schmidt, J.: Doxorubicin chemotherapy in advanced transitional cell carcinoma. Urology 8, 336 (1976)Google Scholar
- 95.Weiss, A., Jackson, L., Carabasi, R.: An evaluation of 5-fluorouracil in malignant disease. Ann. Intern. Med. 55, 731 (1961)Google Scholar
- 95.Whitmore, W. F.: The treatment of bladder tumours. Surg. Clin. North Am. 49, 349 (1969)Google Scholar
- 96.Whitmore, W. F.: Preoperative irradiation of carcinoma of the bladder. In: Modern trends in urology, pp. 204 ff. London: Butterworths 1972Google Scholar
- 97.Whitmore, W. F., Marshall, V. F.: Radical total cystectomy for cancer of the bladder. Two hundred and thirty consecutive cases, five years later. J. Urol. 87, 853 (1962)Google Scholar
- 98.Whitmore, W. F., Grabstadt, H., MacKenzie, A. R., Ishwariah, L., Phillips, R.: Preoperative irradiation with cystectomy in the management of bladder cancer. Am. J. Roentgenol. 102, 570 (1968)Google Scholar
- 99.Williams, S. D., Rohn, R. J., Einhorn, L. H.: Chemotherapy of bladder cancer with cis-diaminodichloroplatinum, adriamycin, and 5-fluorouracil. Proc. Am. Soc. Clin. Oncol. (ASCO) 19, 316 (Abstract C-37) (1978)Google Scholar
- 100.Wilson, W. L.: Chemotherapy of human solid tumours with 5-fluorouracil. Cancer 13, 1230 (1960)Google Scholar
- 101.Woodruff, M. W., Murphy, W. T., Hodson, J. M.: Use of combination 5-fluorouracil and supervoltage irradiation therapy in advanced carcinoma of bladder. A preliminary report. Cancer Chemother. Rep. 21, 123 (1962)Google Scholar
- 102.Woodruff, M. W., Murphy, W. T., Hodson, J. M.: Further observations on the use of combination 5-FU and supervoltage radiation therapy in the treatment of advanced carcinoma of the bladder. J. Urol. 90, 747 (1963)Google Scholar
- 103.Woodruff, M. W., Hardner, C. J., Webster, J., Parghi, G.: Advanced cancer of the urinary bladder. Cancer Bull. 19, 29 (1967)Google Scholar
- 104.Yagoda, A.: Future implications of phase two chemotherapy trials in 95 patients with measurable advanced bladder cancer. Cancer Res. 37, 2775 (1977)Google Scholar
- 105.Yagoda, A., Watson, R. C., Whitmore, W. F., Grabstadt, H., Middleman, M. P., Krakoff, I. H.: Adriamycin in advanced urinary tract cancer. Experience in 42 patients and a review of the literature. Cancer 39, 279 (1977)Google Scholar
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