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Intensive Care Medicine

, Volume 12, Issue 6, pp 429–431 | Cite as

Hypophosphatemia and acute respiratory failure in a diabetic patient

  • L. Hasselstrøm
  • P. D. Wimberley
  • V. G. Nielsen
Case Reports

Abstract

A previously healthy 48-year-old male developed diabetic ketoacidosis and severe hypophosphatemia. Within a few hours, acute respiratory insufficiency developed with a marked discrepancy between the pulmonary pathology and the very poor oxygenation seen. We argue that this was due to the effect of hypophosphatemia on respiratory muscle- and heart function and P50, leading to impaired oxygen delivery.

Key words

Hypophosphatemia Acute respiratory failure Oxyhemoglobin dissociation curve 

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References

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    Agust AGN, Torres A, Estopa R, Agustividal A (1984) Hypophosphatemia as a cause of failed weaning: The importance of metabolic factors. Crit Care Med 12(2):142Google Scholar
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    Ditzel J (1973) Effect of plasma inorganic phosphate on tissue oxygenation during recovery from diabetic ketoacidosis. Adv Exp Med Biol 37A:163Google Scholar
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    Juan D, Elrazak MA (1978) Hypophosphatemia in hospitalized patients. J Am Med Assoc 242:163Google Scholar
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    O'Connor LR, Wheeler WS, Bethune JE (1977) Effect of hypophosphatemia on myocardial performance in man. N Engl J Med 297:901Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • L. Hasselstrøm
    • 1
    • 3
  • P. D. Wimberley
    • 2
  • V. G. Nielsen
    • 2
  1. 1.Department of Anaesthesia, Herlev HospitalUniversity of CopenhagenDenmark
  2. 2.Department of Clinical Chemistry, Herlev HospitalUniversity of CopenhagenDenmark
  3. 3.Department of AnaesthesiaRanders CentralsygehusRandersDenmark

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