, Volume 20, Issue 5, pp 530–534

Effect of strict blood glucose control on residual B-cell function in insulin-dependent diabetics

  • S. Madsbad
  • T. Krarup
  • L. Regeur
  • O. K. Faber
  • C. Binder


In 14 insulin dependent diabetics past their initial remission period B-cell function was evaluated using a test meal before and after 1 week of strict blood glucose control, and again 3 weeks later when the patients were outpatients on conventional therapy. Eight patients with fasting C-peptide above 0.07 nmol/l improved their B-cell function significantly (p<0.05) during the period of strict blood glucose control. However, the improvement was of short duration and was absent 3 weeks later in most patients. Six patients with fasting C-peptide below or equal to 0.07 nmol/l had no significant improvement in B-cell function during the period of strict control. The study shows that B-cell function and degree of blood glucose control are related in patients with fasting C-peptide above 0.07 nmol/l, and that B-cell function can change within days.

Key words

Glycaemic control B-cell function insulin-dependent diabetics C-peptide endogenous insulin secretion 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • S. Madsbad
    • 1
  • T. Krarup
    • 1
  • L. Regeur
    • 1
  • O. K. Faber
    • 1
  • C. Binder
    • 1
  1. 1.Hvidøre HospitalKlampenborgDenmark

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