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Diabetologia

, Volume 26, Issue 1, pp 50–54 | Cite as

Effect of co-ingestion of fat on the metabolic responses to slowly and rapidly absorbed carbohydrates

  • G. Collier
  • A. McLean
  • K. O'Dea
Originals

Summary

The present study examined the acute effects of coingestion of fat (37.5 g) on the post-prandial metabolic responses to 75 g of carbohydrate which was either slowly absorbed (lentils) or rapidly absorbed (potatoes). Co-ingestion of fat resulted in a significant flattening of the post-prandial glucose curves, the effect being more pronounced for the rapidly absorbed potatoes. This was probably due to delayed gastric emptying. However, the post-prandial insulin responses to either carbohydrate were not significantly reduced by fat, suggesting that the insulin response to a given glucose concentration was potentiated in the presence of fat. The gastric inhibitory polypeptide (GIP) responses to both carbohydrates were greatly increased in the presence of fat. To investigate further the possible roles of GIP in the entero-insular axis, a 5-g bolus of glucose was injected intravenously 1 h after lentils ± fat. This was sufficient to raise the glucose levels above the threshold reported for GIP to potentiate insulin secretion. However, despite the large differences in circulating GIP levels, the insulin response to glucose was not affected by the presence of fat. These results suggest that (1) the rate of absorption of carbohydrate is a major determinant of post-prandial metabolic responses even in the presence of fat, (2) fat-stimulated GIP secretion does not potentiate glucose-induced insulin secretion, and (3) the potentiation of the insulin response to glucose when carbohydrate is co-ingested with fat is consistent with the well-documented insulin resistance associated with high fat diets.

Key words

Insulin gastric inhibitory polypeptide insulin sensitivity glucose tolerance diabetes diet fat rate of carbohydrate digestion 

References

  1. 1.
    Anderson JW, Ward K (1978) Long-term effects of high carbohydrate, high fiber diets on glucose and lipid metabolism. A preliminary report on patients with diabetes. Diabetes Care 1: 77–82Google Scholar
  2. 2.
    Simpson RW, Mann JI, Eaton J, Moore RA, Carter R, Hockaday TDR (1979) Improved glucose control in maturity-onset diabetes treated with high carbohydrate-modified fat diet. Br Med J 1: 1753–1756Google Scholar
  3. 3.
    Jenkins DJA, Wolever TMS, Leeds AR, Gasull MA (1978) Dietary fibre, fibre analogues and glucose tolerance: Importance of viscosity. Br Med J 1: 1392–1394Google Scholar
  4. 4.
    O'Dea K, Nestel PJ, Antonoff L (1980) Physical factors influencing postprandial glucose and insulin responses to starch. Am J Clin Nutr 33: 760–765Google Scholar
  5. 5.
    Jenkins DJA, Wolever TMS, Taylor RH, Ghafari H, Jenkins AL, Barker H, Jenkins MJA. (1980) Rate of digestion of foods and postprandial glycaemia in normal and diabetic subjects. Br Med J 281: 14–17Google Scholar
  6. 6.
    Himsworth HP (1935) The dietetic factor determining the glucose tolerance and sensitivity to insulin of healthy men. Clin Sci 2: 67–94Google Scholar
  7. 7.
    Beck-Nielsen H, Pedersen O, Schwartz Sorensen N (1978) Effects of diet on the cellular insulin binding and the insulin sensitivity in young healthy subjects. Diabetologia 15: 289–296Google Scholar
  8. 8.
    Jenkins DJA, Ghafari H, Wolever TMS, Taylor RH, Jenkins AL, Barker HM, Fielden H, Bowling AC (1982) Relationship between rate of digestion of foods and post-prandial glycaemia. Diabetologia 22: 450–455Google Scholar
  9. 9.
    Dupre J, Ross SA, Watson D, Brown JC (1975) The stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 37: 826–828Google Scholar
  10. 10.
    Pederson RA, Schubert HE, Brown JC (1975) Gastric inhibitory polypeptide. Its physiological release and insulinotropic action in the dog. Diabetes 24: 1050–1056Google Scholar
  11. 11.
    Pederson RA, Brown JC (1976) The insulinotropic action of gastric inhibitory polypeptide in the perfused isolated rat pancreas. Endocrinol 99: 780–785Google Scholar
  12. 12.
    Brown JC, Dryburg JR, Ross SA, Dupré J (1975) Identification and actions of gastric inhibitory polypeptide. Recent Prog Horm Res 31: 487–532Google Scholar
  13. 13.
    Falko JM, Crockett SE, Cataland S, Mazzaperri EL (1975) Gastric inhibitory polypeptide stimulated by fat ingestion. J Clin Endocrinol Metab 41: 260–265Google Scholar
  14. 14.
    Morgan LM, Morris BA, Marks V (1978) Radioimmunoassay of gastric inhibitory polypeptide. Ann Clin Biochem 15: 172–177Google Scholar
  15. 15.
    Thomas EJ (1957) Mechanics and regulation of gastric emptying. Physiol Rev 37: 453–474Google Scholar
  16. 16.
    Jenkins DJA, Wolever TMS, Taylor RH, Barker HN, Fielden H (1980) Exceptionally low blood glucose response to dried beans: comparison with other carbohydrate foods. Br Med J 281: 578–580Google Scholar
  17. 17.
    Morgan LM, Goulder TJ, Tsiolakis D, Marks V, Alberti KGMM (1979) The effect of unabsorbable carbohydrate on gut hormones. Modification of post-prandial secretion by guar. Diabetologia 17: 85–89Google Scholar
  18. 18.
    Jenkins DJA, Bloom SR, Albuqerque RH, Leeds AR, Sarson DL, Metz GL, Alberti KGMM (1980) Pectin and complications after gastric surgery. Normalisation of postprandial glucose and endocrine responses. Gut 21: 574–579Google Scholar
  19. 19.
    Collier G, O'Dea K (1982) Effect of physical form of carbohydrate on the postprandial glucose, insulin and gastric inhibitory polypeptide responses in Type 2 diabetes. Am J Clin Nutr 36: 10–14Google Scholar
  20. 20.
    Jenkins DJA, Wolever TMS, Taylor RH, Griffiths C, Ktrzminska K, Lawrie JA, Bennet CM, Goff DV, Sarson DL, Bloom SR (1982) Slow release dietary carbohydrate improves second meal tolerance. Am J Clin Nutr 35: 1339–1346Google Scholar
  21. 21.
    Anderson DK, Elahi D, Brown JC, Tobin JD, Andres R (1978) Oral glucose augmentation of insulin secretion. J Clin Invest 62: 152–161Google Scholar
  22. 22.
    Sarson DL, Wood SM, Holder D, Bloom SR (1982) The effect of glucose-dependent insulinotropic polypeptide infused at physiological concentrations on the release of insulin in man. Diabetologia 22: 33–36Google Scholar
  23. 23.
    Eckel RH, Fujimoto WY, Brunzell JD (1979) Gastric inhibitory polypeptide enhanced lipoprotein lipase activity in cultured preadipocytes. Diabetes 28: 1141–1142Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • G. Collier
    • 1
  • A. McLean
    • 1
  • K. O'Dea
    • 1
    • 2
  1. 1.Baker Medical Research InstituteVictoriaAustralia
  2. 2.Department of Medicine, Repatriation General HospitalUniversity of MelbourneVictoriaAustralia

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