European Journal of Nuclear Medicine

, Volume 11, Issue 2–3, pp 73–75 | Cite as

A comparison of the sensitivity of PET and NMR for in vivo quantitative metabolic imaging

  • A. M. J. Paans
  • W. Vaalburg
  • M. G. Woldring


Using positron emission tomography (PET) in combination with compounds labelled with positron-emitting radionuclides like 11C, 13N and 15O, it is possible to study metabolism in vivo in a non-invasive way. Nuclear magnetic resonance (NMR) imaging takes advantage of the spin of protons in water molecules to measure both their number and relaxation times in vivo, but is, in principle, not limited to protons and can also be used for other nuclei with a non-zero spin, e.g. 13C and 31P. The use of 13C opens the possibility of studying the metabolism of a large number of compounds. In order to choose the appropriate methodology for metabolic imaging, i.e. PET or NMR, it is important to know the sensitivity of each modality. The present study outlines the sensitivity of both techniques.

Key words

Metabolic imaging PET NMR 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Berger G, Maziere M, Prenant C, Sastre J, Comar D (1984) 11C Labelling of a protein: Concanavalin A. Int J Appl Radiat Isot 35:81–83CrossRefPubMedGoogle Scholar
  2. Bloch F, Hansen WW, Packard M (1946) Nuclear induction. Phys Rev 69:127Google Scholar
  3. Bolster JM, Vaalburg W, van Veen W, van Dijk T, van der Molen HD, Wynberg H, Woldring MG (1983) Synthesis of no-carrier-added L- and D-[1-11C]-Dopa. Int J Appl Radiat Isot 34:1650–1652Google Scholar
  4. Bottomley PA, Andrew ER (1978) RF magnetic field penetration, phase shift and power dissipation in biological tissue: Implications for NMR imaging. Phys Med Biol 23:630–643Google Scholar
  5. Budinger TF, Gullberg GT, Huesman RH (1979) Emission computed tomography. In: Herman GT (ed) Image reconstructions from projections. Springer, Berlin Heidelberg New York, pp 147–242Google Scholar
  6. Damadian R (1971) Tumor detection by nuclear magnetic resonance. Science 171:1151–1153Google Scholar
  7. Gadian DG (1982) Nuclear magnetic resonance and its application to living systems. Clarendon Press, OxfordGoogle Scholar
  8. Korf J, Venema K (1983) Amino acids in substantia nigra of rats with striatal lesions produced by kainic acid. J Neurochem 40:1171–1173Google Scholar
  9. Lauterbur PC (1973) Image formation by induced local interactions: Examples employing NMR. Nature 242:190–191Google Scholar
  10. Purcell EM, Torrey HC, Pound HV (1946) Resonance absorption by nuclear magnetic moments in a solid. Phys Rev 69:37–38Google Scholar
  11. Wolf AP (1981) Synthesis of organic compounds labeled, with positron emitters and the carrier problem. J Labelled Compd Radiopharm 18:1–2Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • A. M. J. Paans
    • 1
  • W. Vaalburg
    • 1
  • M. G. Woldring
    • 1
  1. 1.Department of Nuclear MedicineUniversity HospitalGroningenThe Netherlands

Personalised recommendations