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Diabetologia

, Volume 24, Issue 3, pp 207–209 | Cite as

The effect of strict short-term metabolic control on retinal nervous system abnormalities in newly diagnosed Type 1 (insulin-dependent) diabetic patients

  • K. Frost-Larsen
  • J. Sandahl Christiansen
  • H. -H. Parving
Short Communications

Summary

The oscillatory potential of the electroretinogram and the initial 2-min phase of dark-adaptation were studied in seven newly diagnosed Type 1 (insulin-dependent) diabetic patients before and during initial insulin treatment. Strict metabolic control was achieved in all seven patients using multiple subcutaneous injections of insulin. Seven to 11 days of strict metabolic control improved the added amplitude value of the oscillatory potential from 236±8 to 268±8 μV (mean±SEM; p < 0.01) and the dark-adaptation from 90 ±5 to 67±5 s (p < 0.01). Our study has demonstrated reversible neurophysiological abnormalities in the diabetic retina which are related to metabolic control.

Key words

Type 1 diabetes metabolic control dark adaptation electroretinography 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • K. Frost-Larsen
    • 1
  • J. Sandahl Christiansen
    • 2
  • H. -H. Parving
    • 2
    • 3
  1. 1.Eye DepartmentGentofte HospitalCopenhagenDenmark
  2. 2.Steno Memorial HospitalGentofteDenmark
  3. 3.Medical Department FHerlev HospitalCopenhagenDenmark

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