Experimental Brain Research

, Volume 75, Issue 3, pp 599–610 | Cite as

Interference of vibrations with input transmission in dorsal horn and cuneate nucleus in man: a study of somatosensory evoked potentials (SEPs) to electrical stimulation of median nerve and fingers

  • V. Ibañez
  • M. P. Deiber
  • F. Mauguière
Article
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Accepted:

Summary

The effects of 50 Hz palm vibrations on somatosensory potentials (SEPs) evoked by electrical stimulation of the median nerve at the wrist and of the 2nd and 3rd fingers were studied in 10 normal subjects. Vibrations were found to produce attenuation of the N13 spinal and P14 brainstem potentials and of the N20 contralateral parietal response. Brachial plexus (N9, P9) and dorsal column (P11) responses were not modified by vibrations. These SEP findings show: 1) that vibrations do not interfere at the periphery with the processing of brief ascending volleys triggered by an electrical stimulus and 2) that such an interference does occur in spinal dorsal horn and cuneate nucleus. Reduced input transmission in the cuneate nucleus is likely to be responsible for perceptual alterations induced by vibrations.

Key words

Somatosensory evoked potentials Cuneate nucleus Vibrations 
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References

  1. Abbruzzese G, Abbruzzese M, Favale E, Ivaldi M, Leandri M, Ratto S (1980) The effect of hand muscle vibration on the somatosensory evoked potential in man: an interaction between lemniscal and spinocerebellar inputs? J Neurol Neurosurg Psychiat 43: 433–437Google Scholar
  2. Allison T, Goff WR, Williamson PD, Vangilder JC (1980) On the neural origin of early components of the human somatosensory evoked potentials. In: Desmedt JE (ed) Clinical uses of cerebral, brainstem and spinal somatosensory evoked potentials. Progress in clinical neurophysiology, Vol 7. Karger, Basel, pp 51–68Google Scholar
  3. Andersen P, Eccles JC, Oshima T, Schmidt RF (1964) Mechanisms of synaptic transmission in the cuneate nucleus. J Neurophysiol 27: 1096–1116Google Scholar
  4. Andersen P, Etholm B, Gordon G (1970) Presynaptic and postsynaptic inhibition elicited in the cat's dorsal column nuclei by mechanical stimulation of skin. J Physiol (Lond) 210: 433–455Google Scholar
  5. Andres-Trelles F, Cowan CM, Simmonds MA (1976) The negative potential wave evoked in cuneate nucleus by stimulation of afferent pathway: its origins and susceptibility to inhibition. J Physiol (Lond) 258: 173–186Google Scholar
  6. Anziska B, Cracco RQ (1981) Short latency somatosensory evoked potentials to median nerve stimulation: comparison of recording methods and origin of components. Electroenceph Clin Neurophysiol 52: 531–539Google Scholar
  7. Boivie J, Boman K (1981) Termination of a separate (proprioceptive?) cuneothalamic tract from external cuneate nucleus in monkey. Brain Res 224: 235–246Google Scholar
  8. Brown MC, Engberg I, Matthews PBC (1967) The relative sensitivity to vibration muscle receptors of the cat. J Physiol (Lond) 192: 773–800Google Scholar
  9. Burke D, Hagbarth KE, Lofstedt L, Wallin BG (1976) The responses of human muscle spindle endings to vibration of non contracting muscles. J Physiol 261: 673–693Google Scholar
  10. Cracco RQ, Cracco JB (1976) Somatosensory evoked potentials in man: far-field potentials. Electroenceph Clin Neurophysiol 41: 460–466Google Scholar
  11. Deiber MP, Giard MH, Mauguière F (1986) Separate generators for parietal N20 and frontal P22 potentials evoked by finger stimulation. Electroenceph Clin Neurophysiol 65: 321–334Google Scholar
  12. Desmedt JE, Cheron G (1980) Central somatosensory conduction in man: neural generators and interpeaks latencies of the farfield components recorded from neck and right or left scalp and ear lobes. Electroenceph Clin Neurophysiol 50: 382–403Google Scholar
  13. Desmedt JE, Cheron G (1981a) Non-cephalic reference recording of early somatosensory potentials to finger stimulation in adults or aging normal man: differentiation of widespread N18 and contralateral N20 from the prerolandic P22 and N30 components. Electroenceph Clin Neurophysiol 52: 553–570Google Scholar
  14. Desmedt JE, Cheron G (1981b) Prevertebral (oesophageal) recording of subcortical somatosensory evoked potentials in man: the spinal P13 component and the dual nature of the spinal generators. Electroenceph Clin Neurophysiol 52: 257–275Google Scholar
  15. Desmedt JE, Nguyen TH, Carmeliet J (1983) Unexpected latency shifts of the stationary P9 somatosensory evoked potential farfield with changes in shoulder position. Electroenceph Clin Neurophysiol 56: 628–634Google Scholar
  16. Donchine E, Callaway E, Cooper R, Desmedt JE, Doff WR, Hillyard SA, Sutton S (1977) Publication criteria for studies of evoked potentials (E.P.) in man. In: Desmedt JE (ed) Attention, voluntary contraction and event-related cerebral potentials: report of a committee, Vol 1. Karger, Basel, pp 1–11Google Scholar
  17. Eklund G (1972) Position sense and state of contraction: the effects of vibration. J Neurol Neurosurg Psychiat 35: 606–611Google Scholar
  18. Emerson RG, Seyal M, Pedley TA (1984) Somatosensory evoked potentials following median nerve stimulation. I. The cervical components. Brain 107: 169–182Google Scholar
  19. Emerson RG, Pedley TA (1986) Effect of cervical spinal cord lesions on early components of the median nerve somatosensory evoked potential. Neurology 36: 20–26Google Scholar
  20. Ferrington DG, Horniblow S, Rowe MJ (1987) Temporal patterning in the responses of gracile and cuneate neurones in the cat to cutaneous vibration. J Physiol 386: 277–291Google Scholar
  21. Gandevia SC, Burke D, McKeon B (1984) The projection of muscle afferents from the hand to cerebral cortex in man. Brain 107: 1–13Google Scholar
  22. Giuffrida R, Sanderson P, Condes-Lara M, Albe-Fessard D (1986) Cortifugal influences on dorsal column nuclei: an electrophysiological study in the rat using the cortical spreading depression technique. Exp Brain Res 61: 649–653Google Scholar
  23. Goodwin GM, McCloskey DI, Matthews PBC (1972a) The persistance of appreciable kinesthesia after paralysing joint afferents but preserving muscle afferents. Brain Res 37: 326–329Google Scholar
  24. Goodwin GM, McCloskey DI, Matthews PBC (1972b) Proprioceptive illusions induced by muscle vibration: contribution by muscle spindles to perception? Science 175: 1382–1384PubMedGoogle Scholar
  25. Goodwin GM, McCloskey DI, Matthews PBC (1972c) An systematic distorsion of position sense produced by muscle vibration. J Physiol (Lond) 221: 8–9Google Scholar
  26. Goodwin GM, McCloskey DI, Matthews PBC (1972d) The contribution of muscle afferents to kinesthesia shown by vibration induced illusions of mouvement and by the effects of paralysing joint afferents. Brain 95: 705–748Google Scholar
  27. Hallyday AM, Wakefield G (1963) Cerebral evoked potentials in patients with dissociated sensory loss. J Neurol Neurosurg Psychiat 26: 211–219Google Scholar
  28. Hashimoto I (1984) Somatosensory evoked potentials from the human brainstem: origins of short latency potentials. Electroenceph Clin Neurophysiol 57: 221–227Google Scholar
  29. Hummelsheim H, Wiesendanger M (1985) Neuronal responses of medullary relay cells to controlled stretches of forearm muscles in the monkey. Neuroscience 16: 989–996Google Scholar
  30. Hummelsheim H, Wiesendanger R, Wiesendanger M, Bianchetti M (1985) The projection of low threshold muscle afferents of the forelimb to the main and external cuneate nuclei of the monkey. Neuroscience 16: 979–987Google Scholar
  31. Hunt CC (1961) On the nature of vibration receptors in the hind limb of the cat. J Physiol 155: 175–186Google Scholar
  32. Iggo A, Ogawa H (1977) Correlative physiological and morphological studies of rapidly adapting mechanoreceptors in the cat's glabrous skin. J Physiol 266: 275–296Google Scholar
  33. Iragui VJ (1984) The cervical somatosensory evoked potential in Man, far-field conducted, and segmental components. Electroenceph Clin Neurophysiol 57: 228–235Google Scholar
  34. Jones SJ (1979) Investigation of brachial plexus traction lesions by peripheral and spinal somatosensory evoked potentials. J Neurol Neurosurg Psychiat 42: 107–116Google Scholar
  35. Jones SJ (1981) An “interference” approach to the study of somatosensory evoked potentials in man. Electroenceph Clin Neurophysiol 52: 517–530Google Scholar
  36. Lindblom U, Lund L (1966) The discharge from vibration sensitive receptors in the monkey foot. Exp Neurol 15: 401–417Google Scholar
  37. Mauguière F (1983) Les potentiels évoqués somesthésiques cervicaux chez le sujet normal. Analyse des aspect obtenus selon le siège de l'électrode de référence. Rev EEG Neurophysiol Clin 13: 259–272Google Scholar
  38. Mauguière F (1987) Short-latency somatosensory evoked potentials to upper limb stimulation in lesions of brainstem, thalamus and cortex. In: Ellingson RJ, Murray NM, Halliday AM (eds) Electroencephalography and clinical neurophysiology “The London Symposia”, Vol 39. North Holland, Amsterdam, pp 302–309Google Scholar
  39. Mauguière F, Brunon AM, Echallier JF, Courjon JF, Courjon J (1981) Intérêt des potentiels évoqués somesthésiques précoces dans l'exploration des voies de la sensibilité lemniscale. Rev Neurol 137: 1–19Google Scholar
  40. Mauguière F, Desmedt JE, Courjon J (1983a) Astereognosis and dissociated loss of frontal or parietal components of somatosensory evoked potentials in hemispheric lesions: detailed correlations with clinical signs and computerized tomographic scanning. Brain 106: 271–311Google Scholar
  41. Mauguière F, Courjon J, Schott B (1983b) Dissociation of early SEP components in unilateral traumatic section of the lower medulla. Ann Neurol 13: 309–313Google Scholar
  42. Mauguière F, Desmedt JE, Courjon J (1983c) Neural generators of N18 and P14 far-field somatosensory evoked potentials in patients with lesion of thalamus or thalamocortical radiations. Electroenceph Clin Neurophysiol 56: 283–292Google Scholar
  43. Mauguière F, Ibañez V (1985) The dissociation of early SEP components in lesions of the cervico-medullary junction: a cue for routine interpretation of abnormal cervical responses to median nerve stimulation. Electroenceph Clin Neurophysiol 62: 406–420Google Scholar
  44. McCloskey DI (1973) Differences between the senses of mouvement and position shown by the effects of loading and vibration of muscles in man. Brain Res 63: 119–131Google Scholar
  45. Nakanishi T, Shimada Y, Sakuta M, Toyokura Y (1978) The initial positive component of the scalp recorded somatosensory evoked potential in normal subjects and in patients with neurological disorders. Electroenceph Clin Neurophysiol 45: 26–34Google Scholar
  46. Roll JP, Vedel JP (1982) Kinaesthetic role of muscle afferents in man, studied by tendon vibration and microneurography. Exp Brain Res 47: 177–190Google Scholar
  47. Suzuki I, Mayanagi Y (1984) Intracranial recording of short latency somatosensory evoked potentials in man: identification of origin of each component. Electroenceph Clin Neurophysiol 59: 286–296Google Scholar
  48. Talbot WH, Darian-Smith I, Kornhuber HH, Mountcastle VB (1968) The sense of flutter-vibration: comparison of the human capacity with response patterns of mechanoreceptive afferents from the monkey hand. J Neurophysiol 31: 301–334Google Scholar
  49. Torebjörk HE, Hagbarth KE, Eklund G (1978) Tonic finger flexion reflex induced by vibratory activation of digital mechanoreceptors. In: Gordon G (ed) Active touch. The mechanism of recognition of objects by manipulation: a multidisciplinary approach. Pergamon, Oxford, pp 197–203Google Scholar
  50. Urasaki E, Wada S, Kadoya C, Matsuzaki H, Yokota A, Matsuoka S (1988) Absence of spinal N13-P13 and normal scalp far-field P14 in a patient with syringomyelia. Electroenceph Clin Neurophysiol 71: 400–404Google Scholar
  51. Vedel JP, Roll JP (1983) Muscle spindle contribution to the coding of motor activities in man. Exp Brain Res [Suppl] 7: 253–265Google Scholar
  52. Weisberg JA, Rustioni A (1977) Cortical cells projecting to the dorsal column nuclei of rhesus monkey. Exp Brain Res 28: 521–528Google Scholar
  53. Westman J, Blomqvist A, Kohler C, Wu JY (1984) Light and electron microscopic localization of glutamic acid decarboxylase and substance P in the dorsal column nuclei of the cat. Neurosci Lett 26; 51: 347–352Google Scholar
  54. Yamada T, Ishida T, Kudo Y, Rodnitzky RL, Kimura J (1986) Clinical correlates of abnormal P14 in median SEPs. Neurology 6: 765–771Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • V. Ibañez
    • 1
  • M. P. Deiber
    • 1
  • F. Mauguière
    • 1
  1. 1.Laboratoire de Neurophysiologie Sensorielle Appliquée à la CliniqueHôpital NeurologiqueLyonFrance

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