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Archives of Microbiology

, Volume 157, Issue 5, pp 406–410 | Cite as

Biological effects of tolytoxin (6-hydroxy-7-O-methyl-scytophycin b), a potent bioactive metabolite from cyanobacteria

  • Gregory M. L. Patterson
  • Shmuel Carmeli
Original Papers

Abstract

Tolytoxin, a macrocyclic lactone, is a potent antifungal antibiotic, exhibiting MICs in the range of 0.25 to 8 nanomolar. Tolytoxin also inhibits the growth of a variety of mammalian cells at similar doses, without specific inhibition of macromolecular synthesis. The effects in mammalian cells are primarily cytostatic, with cell death being time-and dose-dependent. Tolytoxin is highly toxic to mice, exhibiting an LD50 (ip) of 1.5 mg/kg. No antibacterial, antiviral, or hemolytic activities were observed.

Key words

Cyanobacteria Secondary metabolite Antifungal Cytotoxin 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Gregory M. L. Patterson
    • 1
  • Shmuel Carmeli
    • 1
  1. 1.Department of ChemistryUniversity of HawaiiHonoluluUSA

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