Horizontal optokinetic ocular nystagmus in wildtype (B6CBA+/+) and weaver mutant mice

  • U. Grüsser-Cornehls
  • P. Böhm
Article

Summary

Horizontal optokinetic nystagmus (OKN) evoked by a random dot pattern moving at a constant speed around the animal was investigated in wild-type mice and “Weaver” mutants (cerebellar impairment) by means of chronically implanted EOG-electrodes. The shape of OKN in the homozygotic Weaver mouse was clearly different from that in normal mice. The OKN in the mutant showed inconstant velocity during the slow phase. Nystagmus frequency of the mutant was significantly below that of normal controls for velocities of 1.4 to 25 degrees · s-1. In one group of normals the mean slow-phase gain was relatively constant for stimulus angular velocities between 1.4 and 15 degrees · s-1 and declined thereafter. In a second group the mean slow-phase gam decreased gradually between stimulus angular velocities from 1.4 to 15 degrees · s-1 and thereafter with a steeper slope. In mutants gain decreases with increasing stimulus velocity over the entire range tested (1.4 to 42 degrees · s-1). Normals and mutants with one eye occluded exhibited strong OKN when the pattern was moved in a temporonasal direction; little response was obtained by stimuli moving in a naso-temporal direction.

Key words

OKN Mice Cerebellar impairment Weaver mutant 

References

  1. Baker R, Precht W, Llinás R (1972) Cerebellar modulatory action on the vestibulo-trochlear pathway in the cat. Exp Brain Res 15: 364–385CrossRefPubMedGoogle Scholar
  2. Balkema GW Jr, Mangini NJ, Pinto LH, Vanable JW Jr (1984) Visually evoked eye movements in mouse mutants and inbred strains: a screening report. Invest Ophthal Vis Sci 25: 795–800PubMedGoogle Scholar
  3. Barber HO, Stockwell CW (1980) Manual of electronystagmography, 2nd ed. CV Mosby Company, St Louis Toronto LondonGoogle Scholar
  4. Böhm P, Grüsser-Cornehls U (1982) Optokinetic nystagmus in the mutant “weaver” and in wildtype mice. Neurosci Lett Suppl 10: 83Google Scholar
  5. Braun JJ, Gault FP (1969) Monocular and binocular control of horizontal optokinetic nystagmus in cats and rabbits. J Comp Physiol Psychol 69: 13–16CrossRefGoogle Scholar
  6. Brückner R (1951) Spaltlampenmikroskopie und Ophthalmoskopie am Auge von Ratte und Maus. Docum Ophthal 5–6: 452–554CrossRefPubMedGoogle Scholar
  7. Collewijn H (1969) Optokinetic eye movements in the rabbit: input-output-relations. Vision Res 9: 117–132CrossRefPubMedGoogle Scholar
  8. Collewijn H (1981) The oculomotor system of the rabbit and its plasticity. Springer, Berlin Heidelberg New YorkGoogle Scholar
  9. Fischer AJEM, Huygen PLM, Kuijpers W (1979) Electronystagmography in the laboratory rat. Acta Otolaryngol 88: 412–419CrossRefPubMedGoogle Scholar
  10. Fukuda J, Highstein SM, Ito M (1972) Cerebellar inhibitory control of the vestibulo-ocular reflex investigated in rabbit IIIrd nucleus. Exp Brain Res 14: 511–526CrossRefPubMedGoogle Scholar
  11. Gilman S, Bloedel JR, Lechtenberg R (1981) Disorders of the cerebellum. FA Davis Company, PhiladelphiaGoogle Scholar
  12. Grüsser-Cornehls U (1983) Responses of vestibular neurons from the nucleus vestibularis and the flocculus in wildtype mice and mutants. Soc Neurosci Abstr 8: 524Google Scholar
  13. Grüsser-Cornehls, Plassmann W, Helmchen Ch, Kahle G (1986) Single unit activity in the vestibular nuclei of normal mice and mutant mice with genetic cerebellar defects. Abstr Developments in oculomotor research, IUPS Satellite Meeting, Gleneden Beach, Oregon, July 20–24, 1986, p 11Google Scholar
  14. Helmchen Ch, Thiele A, Grüsser-Cornehls U (1985) Vestibular responses of nucleus vestibularis neurons in wildtype mice and pcd-mutant mice. Pflügers Arch Suppl 405: R56Google Scholar
  15. Hess BJM, Precht W, Reber A, Cazin L (1985) Horizontal optokinetic ocular nystagmus in the pigmented rat. Neuroscience 15: 97–107CrossRefPubMedGoogle Scholar
  16. Hoffmann K-P (1986) Visual inputs relevant for the optokinetic nystagmus in mammals. In: Freund J, Büttner U, Cohen B, Noth J (eds) Progress in brain research, Vol 64. Elsevier Science Publisheres BV (Biomedical Division), pp 75–84Google Scholar
  17. Ito M (1984) The cerebellum and neural control. Raven Press, New YorkGoogle Scholar
  18. Julesz B (1971) Foundations of cyclopean perception. The University of Chicago Press, Chicago LondonGoogle Scholar
  19. Kahle G, Helmchen Ch, Grüsser-Cornehls U (1985) Possible plastic changes or plastic reorganization at the GABA receptor sites in the nucleus vestibularis of mutant mice with cerebellar defects. Pflügers Arch Suppl 405: R56Google Scholar
  20. Kindermann U, Grüsser-Cornehls U (1987a) Visual-vestibular interaction within the vestibular nuclei in wildtype and weaver mutant mice. In: Elsner N, Creutzfeldt O (eds) New frontiers in brain research. Proceedings of the 15th Göttingen Neurobiology Conference. Georg Thieme, Stuttgart New York, p 214Google Scholar
  21. Kindermann U, Grüsser-Cornehls U (1987b) Cerebellar influence upon medial vestibular nucleus neurons in wildtype and weaver mutant mice during visual and vestibular stimulation. Soc Neurosci Abstr 13: 230Google Scholar
  22. Mangini NJ, Vanable JW Jr, Williams MA, Pinto LH (1985) The optokinetic nystagmus and ocular pigmentation of hypopigmented mouse mutants. J Comp Neurol 241: 191–200CrossRefPubMedGoogle Scholar
  23. Mitchiner JC, Pinto LH, Vanable JW Jr (1976) Visually evoked eye movements in the mouse (Mus musculus). Vision Res 16: 1169–1171CrossRefPubMedGoogle Scholar
  24. Montarolo PG, Precht W, Strata P (1981) Functional organization of mechanisms subserving the optokinetic nystagmus in the cat. Neuroscience 6: 231–246CrossRefPubMedGoogle Scholar
  25. Precht W, Blanks RHI, Strata P, Montarolo P (1985) On the role of the subprimate cerebellar flocculus in the optokinetic reflex and visual-vestibular interaction. In: Bloedel JR, Dichgans J, Precht W (eds) Cerebellar functions. Springer, Berlin Heidelberg New York Tokyo, pp 86–108Google Scholar
  26. Rakic P, Sidman RL (1973) Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice. J Comp Neurol 152: 133–162CrossRefPubMedGoogle Scholar
  27. Robinson DA (1974) The effect of cerebellectomy on the cat’s vestibulo-ocular integrator. Brain Res 71: 195–207CrossRefPubMedGoogle Scholar
  28. Sidman RL, Green MC, Appel SH (1965) Catalog of the neurological mutants of the mouse. Harvard University Press, Cambridge MaGoogle Scholar
  29. Sinex DG, Burdette LJ, Pearlman AL (1979) A psychophysical investigation of spatial vision in the normal and reeler mutant mouse. Vision Res 19: 853–857CrossRefPubMedGoogle Scholar
  30. Ter Braak JWG (1936) Untersuchungen über optokinetischen Nystagmus. Arch Neerl Physiol 21: 309–376Google Scholar
  31. Waespe W, Cohen B, Raphan T (1983) Role of the flocculus and paraflocculus in optokinetic nystagmus and visual-vestibular interactions: effects of lesions. Exp Brain Res 50: 9–33CrossRefPubMedGoogle Scholar
  32. Zee DS, Butler PH, Optican LM, Tusa RJ, Grücer G (1982) Effects of bilateral occipital lobectomies on eye movements in monkeys: preliminary observations. In: Roucoux A, Crommelinck M (eds) Physiological and pathological aspects of eye movements. W Junk, The Hague, pp 225–232Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • U. Grüsser-Cornehls
    • 1
  • P. Böhm
    • 1
  1. 1.Department of PhysiologyFreie Universität BerlinBerlin 33

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