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Child's Nervous System

, Volume 7, Issue 2, pp 79–84 | Cite as

Silicone oil-induced hydrocephalus in the rabbit

  • Mare R. Del Bigio
  • J. Edward Bruni
Original Papers

Abstract

Hydrocephalus was induced in adult rabbits by injecting silicone oil into the cisterna magna. Mean intracranial pressure was significantly elevated for approximately 36 h post-injection, during which time maximal ventricular dilatation was attained. Stretching and compression of periventricular tissue and capillaries accompanied dilation of the lateral ventricles. Ventricular dilation promoted mitotic activity among the periventricular astroglia. Ventriculomegaly altered the metabolism of the monoamine neurotransmitters in the cortex, hippocampus, diencephalon, hypothalamus, and brainstem. Ischemic injury to neurons of the hippocampal formation, particularly the dentate gyrus, was observed when hydrocephalus had persisted for more than 4 weeks. Cerebrospinal fluid shunting effectively reversed the neuropathologic changes only when done in the early stages of hydrocephalus. When hydrocephalus persisted for 8 weeks, rapid reversal of changes in the ependyma and periventricular capillaries was prevented largely by periventricular gliosis.

Key words

Cerebral ventricle Cerebral ischemia Cerebrospinal fluid shunting Hydrocephalus Rabbit 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Mare R. Del Bigio
    • 1
  • J. Edward Bruni
    • 2
  1. 1.Department of PathologyUniversity of ManitobaWinnipegCanada
  2. 2.Department of AnatomyUniversity of ManitobaWinnipegCanada

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