Wiederherstellung der krampfhindernden Wirkung der Hexachlorcyclohexane durch Adenosintetraphosphat

  • H. Coper
  • H. Herken
  • W. Koransky
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Summary

A single dose of benzenehexachloride isomeres produces long lasting resistance to Metrazol-convulsions in rats.

Upon its disappearence the inhibition of convulsion can be restored by some commercial samples of ATP.

Purified ATP has no effect in this respect. Adenosinetetraphosphate has been isolated from these effective samples by ion-exchange chromatography.

A dose of 100 μg adenosinetetraphosphate/kg body weight corresponding the amount of ATTP of the injected effective sample restores the described resistance to convulsion.

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Copyright information

© Springer-Verlag 1959

Authors and Affiliations

  • H. Coper
    • 1
  • H. Herken
    • 1
  • W. Koransky
    • 1
  1. 1.Aus dem Pharmakologischen Institut der Freien Universität BerlinGermany

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