Archives of Microbiology

, Volume 158, Issue 5, pp 364–369 | Cite as

Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway by carbon sources and their metabolites

  • Jinyou Zhang
  • Arnold L. Demain
Original Papers
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Accepted:

Abstract

The activity of δ-l-α-aminoadipyl)-l-cysteinyl-d-valine catalysis. Addition of l-cysteine to fermentation media increased β-lactam production in both organisms and alleviated the negative carbon source regulation by glycerol in S. clavuligerus.

Key words

Regulation ACV synthetase activity Glucose Glyceraldehyde-3-phosphate ATP l-cysteine β-Lactams Cephalosporium acremonium Streptomyces clavuligerus 
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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Jinyou Zhang
    • 1
  • Arnold L. Demain
    • 1
  1. 1.Fermentation Microbiology Laboratory, Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA

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