Advertisement

Molecular and Cellular Biochemistry

, Volume 49, Issue 2, pp 65–85 | Cite as

Antigenicity, storage, and aging: physiologic autoantibodies to cell membrane and serum proteins and the senescent cell antigen

  • M. M. B. Kay
  • K. Sorensen
  • P. Wong
  • P. Bolton
Article

Summary

Normal human serum contains autoantibodies to a wide range of cellular and serum proteins. IgG autoantibodies to cell membrane proteins spectrin, syndein (Band 2.1), Band 3 degradation products, and the senescent cell antigen are among them. Physiologic autoantibodies to the senescent cell antigen, a ∼62 000 dalton glycopeptide derived from Band 3, initiate removal of senescent, damaged, and stored cells in vivo. The senescent cell antigen is one of the two Band 3 degradation products (Mr ∼ 66 000 and 62 000) observed in freshly prepared ghosts.

Since the senescent cell antigen is observed on red cells aged in situ, data suggest that Band 3 undergoes proteolysis in situ. IgG eluted from blood stored for transfusion binds to the senescent cell antigen. The amount of IgG on red cells increases during storage suggesting accumulation of the senescent cell antigen. Autoantibodies to other cell and serum proteins are discussed as possible regulators of homeostasis. The effect of age on physiologic autoantibodies is reviewed.

Keywords

Cell Membrane Membrane Protein Human Serum Degradation Product Serum Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kay, M. M. B., 1976. J. Am. Soc. Geriat. 24: 253–257.Google Scholar
  2. 2.
    Kay, M. M. B. Biomembranes 12: Pathological Membranes (Nowotny, A., ed.) Plenum Publishing Corp, New York, in the press.Google Scholar
  3. 3.
    Bennett, G. D. and Kay, M. M. B., 1981. Exp. Hematol. 9: 297–307.Google Scholar
  4. 4.
    Kay, M. M. B., 1975. Proc. Nat'l. Acad. Sci. USA 72: 3521–3525.Google Scholar
  5. 5.
    Kay, M. M. B., 1978. J. Supramol. Struct 9: 555–567.Google Scholar
  6. 6.
    Murphy, J. R., 1973. J. Lab. Clin. Med. 82: 334.Google Scholar
  7. 7.
    Kochwa, S. and Rosenfield, R., 1964. J. Immunol. 92: 682.Google Scholar
  8. 8.
    Marchesi, V. T. and Andrews, E. P., 1971. Science 174: 1247.Google Scholar
  9. 9.
    Hollister, P. J., Bennett, G. D., Onari, K., Kay, M. M. B. and Makinodan, T., 1980. Proc. Western Gerontological Society Meeting.Google Scholar
  10. 10.
    Silverberg, M., Furthmayr, H., Marchesi, V. T., 1976. Biochemistry 15: 1448–1454.Google Scholar
  11. 11.
    Steck, T. L., 1974. J. Biol. Chem. 62: 1–19.Google Scholar
  12. 12.
    Furthmayr, H., 1978. J. Supramol. Struct. 9: 79–95.Google Scholar
  13. 13.
    Furthmayr, H., Tomita, M. and Marchesi, V. T., 1975. Biochem. Biophys. Res. Commun. 65: 113–121.Google Scholar
  14. 14.
    Prohaska, R., Koerner, T. A. W., Armitage, I. M. and Furthmayr, H., 1981. J. Biol. Chem. 256: 5781–5791.Google Scholar
  15. 15.
    Bennett, V. and Branton, D., 1977. J. Biol. Chem. 252: 2753–2763.Google Scholar
  16. 16.
    Goodman, S. R. and Weidner, S. A., (1980). J. Biol. Chem. 255: 8082–8086.Google Scholar
  17. 17.
    Nakashima, K. and Beutler, B., 1979. Proc. Natl. Acad. Sci. USA 76: 935–938.Google Scholar
  18. 18.
    Tyler, J. M., Hargreaves, W. R. and Branton, D., 1979. Proc. Nat'l. Acad. Sci. USA 76: 5192–5196.Google Scholar
  19. 19.
    Yu, J. and Steck, S. L., 1975. J. Biol. Chem. 250: 9170–9175.Google Scholar
  20. 20.
    Tanner, M. J. A. and Boxer, D. H., 1972. Biochem. J. 129: 333–347.Google Scholar
  21. 21.
    Fairbanks, G., Steck, T. L. and Wallach, D. F. H., 1971. Biochemistry 10: 2606.Google Scholar
  22. 22.
    Eckhardt, A. E., Hayer, C. E. and Goldstein, I. J., 1976. Anal. Biochem. 73: 192.Google Scholar
  23. 23.
    Lutz, H. U., von Daniken, A., Semenza, G. and Bachi, T. H., 1979. Biochem. Biophys. Acta 552: 262.Google Scholar
  24. 24.
    Cochrum, K., Hanes, D., Fagan, G., Speybroeck, J. V. and Sturtevant, F. K., 1978. Transplant. Proc. 10: 867.Google Scholar
  25. 25.
    Kay, M. M. B., 1980. Aging Phenoma: Relationships among Different Levels of Organization (Oota, K., Makinodan, T., Iriki, M. and Baker, L. S., eds.) Plenum Press, New York.Google Scholar
  26. 26.
    Kay, M. M. B., 1981. Acta Biol. Med. Germ. 40:395–391.Google Scholar
  27. 27.
    Kay, M. M. B. UCLA Forum in Medical Sciences, 251, Academic Press, New York, in the press.Google Scholar
  28. 28.
    Kay, M. M. B. Protides of the biological Fluids, 29th Colloquium (Peeters, H., ed.) Pergammon Press, Oxford, in the press.Google Scholar
  29. 29.
    Kay, M. M. B., 1981. Nature 289: 491–494.Google Scholar
  30. 30.
    Axelsen, N. H., Kroll, J. and Weeke, B., ed., 1973. Quantitative Immunoelectrophoresis (Universitetsforlaget, Oslo).Google Scholar
  31. 31.
    Martin, W. J. and Martin, S. E., 1975. Nature 254: 716.Google Scholar
  32. 32.
    Roder, J. C., Bell, D. A. and Singhal, S. K., 1978. J. Immunol. 121: 38–43.Google Scholar
  33. 33.
    Dresser, D. W. and Popham, A. M., 1976. Nature 264: 552–556.Google Scholar
  34. 34.
    Dresser, D. W., 1978. Nature 274: 480–483.Google Scholar
  35. 35.
    Lutz, H. U. and Kay, M. M. B., 1981. Mech. Ageing Dev. 15:65–75.Google Scholar
  36. 36.
    Glass, G. A. and Gershon, D., 1981. XII International Congress of Gerontology, Hamburg, pp. 119.Google Scholar
  37. 37.
    Bartosz, G., Soszyński, M. and Wasilewski, A., 1982. Mech. Ageing Dev. 19: 45–52.Google Scholar
  38. 38.
    Kay, M. M. B., 1974. Gerontologist 14: 33.Google Scholar
  39. 39.
    Steck, T. L. and Yu, J., 1973. J. Supramol. Struct. 1: 220–232.Google Scholar
  40. 40.
    Steck, T. L., Ramos, B. and Strapazon, E., 1976. Biochemistry 15: 1154.Google Scholar
  41. 41.
    Towbin, H., Staehelin, T. and Gordon, J., 1979. Proc. Natl. Acad. Sci. USA 76: 4350–4354.Google Scholar
  42. 42.
    Beutler, E., West, C. and Blume, K.-G., 1976. J. Lab. Clin. Med. 88: 328–333.Google Scholar
  43. 43.
    Piomelli, S., Seaman, C., Reibman, J., Tytun, A., Graziano, J., Tabachnik, N. and Corash, L., 1978. L. Proc. Natl. Acad. Sci. USA 75: 3474–3478.Google Scholar
  44. 44.
    Moskowitz, M., 1955. Nature 175: 595.Google Scholar
  45. 45.
    Conrad, M. J. and Penniston, J. T., 1974. Vex Sang 26: 1–13.Google Scholar
  46. 46.
    Tannert, Ch., 1978. Untersuchungen zum altern roter blutzellen, Ph.D. Dissertation, Humbolt University, Berlin, GDR.Google Scholar
  47. 47.
    Wegner, G., Tannert, Ch., Maretzki, D., Schossler, W. and Strauss, D., 1980. IXth International Symposium on Structure and Function of Erythroid Cells, Berlin, p. 57.Google Scholar
  48. 48.
    Halbhuber, K.-T., Stibenz, D., Feuerstein, H., Linss, W., Meyer, H.-W., Frober, R., Rumpel, E. and Geyer, G., 1980. IXth Internat. Symp. Structure and Function of Erythroid Cells, Berlin, GDR, p. 66.Google Scholar
  49. 49.
    Syllm-Rapoport, L, Jacobasch, G., Prehn, S. and Rapoport, S., 1969. Blood 33: 617.Google Scholar
  50. 50.
    Steck, T. L., 1978. J. Supramol. Struct. 8: 311–324.Google Scholar
  51. 51.
    Markowitz, S. and Marchesi, V. T., 1981. J. Biol. Chem. 256: 6463–6468.Google Scholar
  52. 52.
    Golovtchenko-Matsumoto, A. M. and Osawa, T., 1980. J. Biochem. 87: 847–854.Google Scholar
  53. 53.
    Bjerrum, O. J., 1981. Membrane proteins A Laboratory Manual (Azzi, A., Brodbeck, U. and Zahler, P., eds.) pp. 13–42, Springer-Verlag, Berlin.Google Scholar
  54. 54.
    Hakomori, S., 1981. Seminars in Hematology 18: 39–62.Google Scholar
  55. 55.
    Lutz, H. U., 1981. Acta Biol. Med. Germ. 40: 393–400.Google Scholar
  56. 56.
    Alderman, E. M., Fudenbert, H. H. and Lovins, R. E., 1981. Blood 58: 341.Google Scholar
  57. 57.
    Kay, M. M. B. and Bennett, G. D., 1982. Blood 59: 1111–1112. (letter)Google Scholar
  58. 58.
    Yu, J., Fischman, D. A. and Steck, T. L., 1973. J. Supramol. Struct. 1: 233–247.Google Scholar
  59. 59.
    Stanworth, D. R. and Turner, M. W., 1978, Handbook of Experimental Immunology (Weir, D. M., ed.) Vol. 1 Immunochemistry, p. 651, Blackwell, Oxford.Google Scholar
  60. 60.
    Mollison, P. L., 1979. Blood Transfusion in Clinical Medicine, p. 405 Blackwell, Oxford.Google Scholar
  61. 61.
    Race, R. R. and Sanger, R., 1975. Blood Groups in Man. p. 486 Blackwell, Oxford.Google Scholar
  62. 62.
    Issitt, P. D. and Issitt, C. H., 1979. Applied Blood Group Serology. p. 261, Spectra Biologicals, Oxnard.Google Scholar
  63. 63.
    Jancik, J. and Schauer, R., 1974. Hoppe-Seyler's Z. Physiol. Chem. 355: 395–400.Google Scholar
  64. 64.
    Durocher, J. R., Payne, R. C. and Conrad, M. E., 1975. Blood 45: 11–20.Google Scholar
  65. 65.
    Jancik, J. M., Schauer, R., Andres, K. H. and von During, M., 1978. Cell Tiss. Res. 186: 209–226.Google Scholar
  66. 66.
    Aminoff, D., Bell, W. C., Fulton, I. and Ingebrigsten, N., 1976. Amer. J. Hematol. 1: 419–432.Google Scholar
  67. 67.
    Aminoff, D., Bruegge, W. F. W., Bell, W. C., Sarpolis, K. and Williams, R., 1977. Proc. Nat'l. Acad. Sci. USA 74: 1521–1524.Google Scholar
  68. 68.
    Baxter, A. and Beeley, J. G., 1978. Biochem. Biophys. Res. Commun. 83: 466.Google Scholar
  69. 69.
    Lutz, H. U. and Fehr, 1979. J. Biol. Chem. 254: 11177–11184.Google Scholar
  70. 70.
    Lambré, C. R., Kazatchkine, M. D., Maillet, F. and Thibon, M., 1982. J. Immunol. 128: 629–634.Google Scholar
  71. 71.
    Hübener, G., 1925. Z Immun-Forsch 45: 223.Google Scholar
  72. 72.
    Thomsen, O., 1927. Z Immun-Forsch 52: 85.Google Scholar
  73. 73.
    Friedenreich, V., 1930. The Thomsen Hemagglutination Phenomenon, Levin and Munksgaard, Copenhagen.Google Scholar
  74. 74.
    Chu, C. M., 1948. Nature (London) 161: 606.Google Scholar
  75. 75.
    France, M., Nordt, F. J., Corfield, A. and Schauer, R., 1981. Acta Biol. Med. Germ. 40: 415–418.Google Scholar
  76. 76.
    Fechheimer, M., Daiss, J. L. and Cebra, J., 1979. Molecular Immunol. 16: 881–888.Google Scholar
  77. 77.
    Cunningham, A. J., 1976. Transplant. Rev. 31: 23–43.Google Scholar
  78. 78.
    Steele, E. J. and Cunningham, A. J., 1978. Nature 274: 483–484.Google Scholar
  79. 79.
    Cox, K. O. and Cunliffe, D. A., 1979. Clin. Immunol. Immunopathol. 13: 394–401.Google Scholar
  80. 80.
    Shearer, G. M., 1974. Eur. J. Immunol. 4: 527–533.Google Scholar
  81. 81.
    Levine, P., 1978. Proc. Natl. Acad. Sci. USA 75: 5697–5701.Google Scholar
  82. 82.
    Tung, K. S. K., 1975. Clin. Exp. Immunol. 20: 93–104.Google Scholar
  83. 83.
    Fidalgo, B. V., Katayama, Y. and Najjar, V. A., 1967. Biochemistry 6: 3378–3385.Google Scholar
  84. 84.
    Fidalgo, B. V. and Najjar, V., 1967. Biochemistry 6: 3386–3392.Google Scholar
  85. 85.
    Najjar, V. A., 1974. Advances in Enzymology (Meister, A., ed.) Vol. 41, pp. 129–178, John Wiley, Baltimore.Google Scholar
  86. 86.
    Victoria, J., Mahan, L. C. and Masouredis, S. P., 1981. Proc. Natl. Acad. Sci. USA 78: 2898–2902.Google Scholar
  87. 87.
    Victoria, E. J., Mahan, L. C. and Masouredis, S. P., 1982. Brit. J. Hematol. 50: 101–110.Google Scholar
  88. 88.
    Moore, S., Woodrow, C. F. and McClelland, D. B. L., 1982. Nature 295: 529–531.Google Scholar
  89. 89.
    Lorusso, D. J. and Green, F. A., 1975. Science 188: 66–67.Google Scholar
  90. 90.
    Green, F. A., 1972. J. Biol. Chem. 247: 881–887.Google Scholar
  91. 91.
    Rearden, A. and Masouredis, S. P., 1981. Vox Sang 4l: 160–164.Google Scholar
  92. 92.
    Margni, R. A., Jahos, S., Manghi, M., Perdigon, G. and Leoni, J., 1974. Immunology 27: 863–870.Google Scholar
  93. 93.
    Miyama-Inaba, M., Suzuki, T., Paku, Y-H and Masuda, T., 1982. J. Immunol. 128: 882–887.Google Scholar
  94. 94.
    Rivnay, B., Gloverson, A. and Shinitzky, M., 1979. Mech. Ageing Dev. 10: 71–78.Google Scholar
  95. 95.
    Gozes, Y., Umiel, T., Meshorer, A. and Trainin, N., 1978. J. Immunol. 121: 2199–2204.Google Scholar
  96. 96.
    Callard, R. E., Basten, A. and Blanden, R. V., 1979. Nature 281: 218–220.Google Scholar
  97. 97.
    Kay, M. M. B., 1979. Clin. Immunol. Immunopathol. 12: 301–315.Google Scholar
  98. 98.
    Kay, M. M. B., Mendoza, J., Hausman, S. and Dorsey, B., 1979. Mech. Ageing 11: 347–362.Google Scholar
  99. 99.
    Kay, M. M. B., 1978. Original Article Series, Genetic Effects on Ageing (Bergsma, D. and Harrison, D., eds.) Vol. XIV, pp. 213–240 R. Liss, Inc., New York.Google Scholar
  100. 100.
    Kay, M. M. B., 1981. Immunodeficiency Disorders (Chandra, R. K., ed.) Churchill Livingstone, Edinburgh, (in the press).Google Scholar
  101. 101.
    Rodkey, L. S., 1974. J. Exp. Med. 139: 712–720.Google Scholar
  102. 102.
    Brown, J. C. and Rodkey, L. S., 1979. J. Exp. Med. 150: 67–85.Google Scholar
  103. 103.
    Jerne, N. K., 1974. Ann. Immunol. (Paris) 125c: 373.Google Scholar
  104. 104.
    Kluskens, L. and Kohler, H., 1974. Proc. Natl. Acad. Sci. USA 71: 5083–5087.Google Scholar
  105. 105.
    Cosenza, H., 1976. Eur. J. Immunol. 6: 114.Google Scholar
  106. 106.
    Schrater, A. F., Goidl, E. A., Thorbecke, G. J. and Siskind, G. W., 1979. J. Exp. Med. 150: 138–153.Google Scholar
  107. 107.
    Vos, G. H., 1977. Vox Sang 33: 16–20.Google Scholar
  108. 108.
    Scribner, D. J., Weiner, H. L. and Moorhead, J. W., 1978. J. Immunol. 121: 377–382.Google Scholar
  109. 109.
    Kay, M. M. B., 1979. Recent Advances in Gerontology (Orimo, H., Shimada, K., Iriki, M. and Maeda, D., eds.) pp. 442–443, Excerpta Medica, Amsterdam.Google Scholar
  110. 110.
    Makinodan, T. and Kay, M. M. B., 1980. Adv. Immunol. 29: 287–330.Google Scholar
  111. 111.
    Szewczuk, M. R. and Campbell, R. J., 1980. Nature 286: 164–166.Google Scholar
  112. 112.
    Kay, M. M. B. and Makinodan, T., 1981. Prog. Allergy 29: 134–181.Google Scholar
  113. 113.
    Swartzendruber, D. C., 1964. Blood 24: 432–442.Google Scholar
  114. 114.
    Jerne, N. K., Nordin, A. A. and Henry, C., 1963. Cell-Bound Antibodies (Amos, D. B. and Koprowski, H., eds.) pp. 109–125, Wistar Press, Philadelphia.Google Scholar
  115. 115.
    Schooley, J. C., 1961. J. Immunol. 86: 331–337.Google Scholar
  116. 116.
    Congdon, C. C. and Makinodan, T., 1961. Am. J. Path. 39: 697–709.Google Scholar
  117. 117.
    Makinodan, T. and Albright, J. F., 1962. J. Cell. Comp. Physiol. 60 (Suppl. 1): 129.Google Scholar
  118. 118.
    Grubb, A. O., 1975. Scand, J. Immunol. 4 (Suppl. 2) 2: 53.Google Scholar
  119. 119.
    Mihaescu, S., Lenkei, R. and Ghitie, V., 1981. J. Immunol. Meth. 42: 187–193.Google Scholar
  120. 120.
    Fong, S., Tsoukas, C., Frincke, L., Lawrence, S., Holbrook, T., Vaughan, J. and Carson, D., 1981. J. Immunol. 126: 910–921.Google Scholar
  121. 121.
    Tsoukas, C., Carson, D., Fong, S., Pasquali, J.-L. and Vaughan, J., 1980. J. Immunol. 125: 1125.Google Scholar
  122. 122.
    Bartos, D., Bartos, F., Campbell, R. A. and Grettie, D. P., 1980. Science 108: 1178.Google Scholar
  123. 123.
    Furuichi, K., Ezoe, H., Obara, T. and Oka, T., 1980. Proc. Natl. Acad. Sci. USA 77: 2904.Google Scholar
  124. 124.
    Grabar, P., 1975. Clin. Immunol. Immunopathol. 4: 453–466.Google Scholar
  125. 125.
    Kay, M. M. B. and Makinodan, T., 1978. Clinical Immunochemistry. Chemical and Cellular Bases and Applications in Disease (Natelson, Pesce, A. J. and Dietz, A. A., eds.) pp. 192–199, Am. Assoc. Clin. Chem., Wash., D.C.Google Scholar
  126. 126.
    Kay, M. M. B., 1980. Aging, Immunity and Arthritic Disease (Kay, M. M. B., Galpin, J. and Makinodan, T., eds.) Vol. 11, pp. 33–78, Raven Press, New York.Google Scholar

Copyright information

© Martinus Nijhoff, Dr W. Junk Publishers 1982

Authors and Affiliations

  • M. M. B. Kay
    • 1
  • K. Sorensen
    • 1
  • P. Wong
    • 1
  • P. Bolton
    • 1
  1. 1.Division of Geriatric Medicine, Texas A & M University College of MedicineOlin E. Teague Veterans' CenterTempleU.S.A.

Personalised recommendations