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Experimental Brain Research

, Volume 58, Issue 1, pp 208–211 | Cite as

Unit activity related to spontaneous saccades in frontal dorsomedial cortex of monkey

  • J. Schlag
  • M. Schlag-Rey
Research Note

Summary

Single unit activity was studied in the dorsomedial edge of the frontal lobe, above the superior arcuate sulcus in three trained monkeys (Macaca nemestrina). Gaze and head movements were recorded with two magnetic search coils. Discharges preceding spontaneous eye movements in a preferred direction were consistently observed in light and in dark, in a limited cortical territory at the anterior border of the supplementary motor area. Microstimulation at these sites elicited saccades in the unit preferred direction. Five presaccadic units were studied head fixed and head free and showed the same saccade-related activity under both conditions. Preliminary data suggest that the area studied may be a supplementary eye field distinct from the arcuate frontal eye field.

Key words

Supplementary eye field Presaccadic discharges Spontaneous saccades Dorsomedial frontal cortex 

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References

  1. Bizzi E (1968) Discharge of frontal eye field neurons during saccadic and following eye movements in unanesthetized monkeys. Exp Brain Res 6: 69–80Google Scholar
  2. Becker W, Hoehne O, Iwase K, Kornhuber HM (1972) Bereitschaftspotential, prämotorische Positivierung und andere Hirnpotentiale bei sakkadischen Augenbewegungen. Vision Res 12: 421–436Google Scholar
  3. Brinkman C, Porter R (1979) Supplementary motor area in the monkey: activity of neurons during performance of a learned motor task. J Neurophysiol 42: 681–709Google Scholar
  4. Brown TG (1922) Reflex orientation of the optical axes and the influence upon it of the cerebral cortex. Arch Neerl Physiol 7: 571–578Google Scholar
  5. Bruce CJ, Goldberg ME (1985) Primate frontal eye fields; I. Single neurons discharging before saccades. J Neurophysiol (in press)Google Scholar
  6. Jürgens U (1984) The efferent and afferent connections of the supplementary motor area. Brain Res 300: 63–81Google Scholar
  7. Kirzinger V, Jürgens V (1982) Cortical lesion effects and vocalization in the squirrel monkey. Brain Res 233: 299–315Google Scholar
  8. Laplane D, Talairach J, Meininger V, Bancaud J, Orgogozo JM (1977) Clinical consequences of corticectomies involving the supplementary motor area in man. J Neurol Sci 34: 301–314Google Scholar
  9. Leichnetz G (1980) An anterogradely-labeled prefrontal corticooculomotor pathway in the monkey demonstrated with HRP gel and TMB neurochemistry. Brain Res 198: 440–445Google Scholar
  10. Leichnetz GR, Spencer RF, Smith DJ (1984) Cortical projections to nuclei adjacent to the oculomotor complex in the medial dien-mesencephalic tegmentum in the monkey. J Comp Neurol 228: 359–387Google Scholar
  11. Lestienne F, Vidal PP, Berthoz A (1984) Gaze changing behavior in head restrained monkey. Exp Brain Res 53: 349–356Google Scholar
  12. Libet B, Gleason CA, Wright EW, Pearl DK (1983) Time of conscious intention to act in relation to onset of cerebral activity (readiness-potential). Brain 106: 623–642Google Scholar
  13. Mountcastle VB, Lynch JC, Georgopoulos A, Sakata H, Acuna C (1975) Posterior parietal association cortex of the monkey: command functions for the operations within extrapersonal space. J Neurophysiol 38: 871–908Google Scholar
  14. Orgogozo JM, Larsen B (1979) Activation of the supplementary motor area during voluntary movements in man suggests it works as a supramotor area. Science 206: 847–850Google Scholar
  15. Rubens (1975) Aphasia with infarction in the territory of the anterior cerebral artery. Cortex 11: 239–250Google Scholar
  16. Schlag J, Schlag-Rey M (1970) Induction of oculomotor responses by electrical stimulation of the prefrontal cortex of the cat. Brain Res 22: 1–13Google Scholar
  17. Woolsey CN, Settlage PH, Meyer DR, Spencer W, Hamuy TP, Travis AM (1952) Patterns of localization in the precentral and “supplementary” motor area and their relation to the concept of a premotor area. Res Publ Assoc Res Nerv Ment Dis 30: 238–264Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • J. Schlag
    • 1
  • M. Schlag-Rey
    • 1
  1. 1.Department of Anatomy and Brain Research InstituteUniversity of CaliforniaLos AngelesUSA

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