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Experimental Brain Research

, Volume 58, Issue 1, pp 202–205 | Cite as

Spontaneous and evoked release of endogenous Zn2+ in the hippocampal mossy fiber zone of the rat in situ

  • G. Charton
  • C. Rovira
  • Y. Ben-Ari
  • V. Leviel
Research Note

Summary

In rats anaesthetized with urethane, push pull cannulae were stereotaxically introduced in the hippocampus (bilaterally) and Zn2+ assayed in the perfusate by atomic absorption spectrophotometry. When the cannula was located in the immediate vicinity of the mossy fiber zone, both spontaneous and K+ evoked release of Zn2+ were observed, this release was associated with a reduction in the histologically demonstrable Zn2+ as assessed by means of the Timm's stain. Neither spontaneous nor evoked release of Zn2+ was observed when the cannula was located in the medial part of CA1, the fimbria or the thalamus. These observations suggest that Zn2+ is released in the mossy fiber zone.

Key words

Zn2+ Push pull Mossy fibers Hippocampus 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • G. Charton
    • 1
  • C. Rovira
    • 1
  • Y. Ben-Ari
    • 1
  • V. Leviel
    • 1
  1. 1.Laboratoire de Physiologie Nerveuse, Département de Neurophysiologie appliquéeC.N.R.S.Gif-sur-YvetteFrance

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