Experimental Brain Research

, Volume 62, Issue 2, pp 373–386 | Cite as

The development and recovery of motor function in spinal cats

I. The infant lesion effect
  • G. A. Robinson
  • M. E. Goldberger


Normal development of motor function was compared to that of cats with spinal transections at birth (newborn operates) or at approximately two weeks after birth (two week operates). Newborn operates expressed motor behavior not seen until sometime later in normal newborn cats, suggesting that this behavior is normally suppressed by descending systems in newborn cats. After reaching adulthood, the motor performance of newborn operates surpassed that of both two week operates and chronic adult operates (cats with spinal cord transection in adulthood), suggesting that the earlier transection occurs, the greater the recovery of motor function. Transection at birth may alter the course of spinal cord development, accounting for the differences in motor performance among the three age groups.

Key words

Development Cats Transection Spinal cord Paraplegia 


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  1. Amassian VE, Ross RJ (1978) Developing role of sensorimotor cortex and pyramidal tract neurons in contact placing. J Physiol Paris 74: 165–184Google Scholar
  2. Bard P (1933) Studies on cerebral cortex. I. Localized control of placing and hopping reactions in cat motorsensory cortex. J Neurophysiol 30: 40–79Google Scholar
  3. Bregman B, Goldberger ME (1982) Anatomical plasticity and sparing of function after spinal cord damage in neonatal cats. Science 217: 553–555Google Scholar
  4. Bregman B, Goldberger ME (1983) Infant lesion effect: I. Development of motor behavior following neonatal spinal cord damage in cats. Develop Brain Res 9: 103–117Google Scholar
  5. Conradi S, Skoglund S (1969) Observations on the ultrastructure and distribution of neuronal and glial elements on the motoneuron surface in the lumbosacral spinal cord of the cat during postnatal development. Acta Physiol Scand Suppl 333: 5–65Google Scholar
  6. Edgerton VR, Grillner S, Sjostrom A, Zangger P (1976) Central generation of locomotion in vertebrates. In: Herman RM et al. (eds) Neural control of locomotion. Plenum, New YorkGoogle Scholar
  7. Eidelberg E, Walden JG, Nyguyen LH (1981) Locomotor control in macaque monkeys. Brain 104: 647–663Google Scholar
  8. Forssberg H, Grillner S, Sojstrom A (1974) Tactile placing reactions in chronic spinal kittens. Acta Physiol Scand 92: 114–120Google Scholar
  9. Forssberg H, Grillner S, Halbertsma J, Rossignol S (1980) The locomotion of the low spinal cat. II. Interlimb coordination. Acta Physiol Scand 108: 283–295Google Scholar
  10. Forssberg H, Svartengren G (1983) Hardwired locomotor network in cat revealed by a retained motor pattern to gastrocnemius after muscle transposition. Neurosci Lett 41: 283–288Google Scholar
  11. Giuliani CA, Carter MC, Smith JL (1983) Return of weightsupported locomotion in adult spinal cats. Soc Neurosci Abstr 9:632Google Scholar
  12. Grillner S (1973) Locomotion in the spinal cat. In: Stein RB et al. (eds) Control of posture and locomotion. Plenum, New York pp 515–535Google Scholar
  13. Grillner S (1975) Locomotion in vertebrates: control mechanisms and reflex interaction. Physiol Rev 55: 247–304Google Scholar
  14. Grillner S (1976) Some aspects on the descending control of spinal circuits generating locomotor movements. In: Herman RM et al. (eds) Neural control of locomotion. Plenum, New YorkGoogle Scholar
  15. Grillner S, Zangger P (1979) On the central generation of locomotion in the low spinal cat. Exp Brain Res 34: 241–261Google Scholar
  16. Hicks SP, D'Amato CJ (1970) Motor-sensory and visual behaviour after hemispherectomy in newborn and mature rats. Exp Neurol 29: 416–438Google Scholar
  17. Humason GL (1979) Animal tissue techniques. Freeman, San Francisco, pp 416–438Google Scholar
  18. Kennard MA (1936) Age and other factors in motor recovery from precentral lesions in monkeys. Am J Physiol 115: 138–148Google Scholar
  19. Kuypers HJ, Huisman AM (1982) The new anatomy of the descending brain pathways. In: Sjölund B, Björklund A (eds) Brainstem control of spinal mechanisms. Elsevier Biomedical, Amsterdam, pp 120–146Google Scholar
  20. Leonard CT, Robinson GA, Goldberger ME (1983) Development and recovery of function in neonatally brain damaged cats. Soc Neurosci Abstr 9: 61Google Scholar
  21. Leonard CT, Robinson GA, Goldberger ME (1984) The exuberance of youth: an analysis of corticospinal, corticothalamic and corticorubral projections in one day old cats. Soc Neurosci Abstr 10: 322Google Scholar
  22. Malcolm JL (1955) The appearance of inhibition in the developing spinal cord of kittens. In: Waelsch H (ed) Biochemistry of the developing nervous system. Academic, New York, pp 104–109Google Scholar
  23. Martin GF, Cabana T, Ditirro FJ, Ho RH, Humbertson AO (1982) The development of descending spinal connections. Studies using the North American opossum. In: Kuypers HGJM, Martin GF (eds) Descending pathways to the spinal cord, progress in brain research. Elsevier, Amsterdam, pp 131–144Google Scholar
  24. McCouch GP, Austin GM, Liu CN, Liu CY (1958) Sprouting as a cause of spasticity. J Neurophysiol 21: 205–216Google Scholar
  25. Mellstrom A, Skoglund S (1969) Quantitative morphological changes in some spinal cord segments during postnatal development. A study in the cat. Acta Physiol Scand Suppl 331: 2–84Google Scholar
  26. Miller S, Burg J van der, Meche FGA van der (1975) Coordination of the movements of the hindlimbs and forelimbs in different forms of locomotion in normal and decerebrate cats. Brain Res 91: 217–237Google Scholar
  27. Murray M, Goldberger ME (1974) Restitution of function and collateral sprouting in the cat spinal cord: the partially hemisected animal. J Comp Neurol 158: 19–36Google Scholar
  28. Rademaker VGGJ (1931) Standing: static reactions equilibrium and muscle tonus with special consideration of their retention in animals without a cerebellum. In: Das Stechen. Springer, BerlinGoogle Scholar
  29. Reh T, Kalil K (1981) Development of the pyramidal tract in the hamster. I. A light microscopic study. J Comp Neurol 200: 55–67Google Scholar
  30. Robinson GA, Goldberger ME (1986) The development and recovery of motor function in spinal cats. II. Pharmacological enhancement of recovery. Exp Brain Res 62: 387–400Google Scholar
  31. Ronnevi L (1977) Spontaneous phagocytosis of boutons on spinal motoneurons during early postnatal development. An electron microscopic study in the cat. J Neurocytol 6: 487–504Google Scholar
  32. Shurrager PS, Dykman RA (1951) Walking spinal carnivores. J Comp Physiol Psychol 44: 252–262Google Scholar
  33. Skoglund S (1960) On the postnatal development of the postural reflexes as revealed by electromyography and myography in decerebrate kittens. Acta Physiol Scand 49: 299–317Google Scholar
  34. Skoglund S (1969) Reflex maturation. In: Brazier MAB (ed) The interneuron. University of California Press, Los Angeles, pp 131–159Google Scholar
  35. Smith JL, Smith LA, Zernicke RF, Hoy M (1982) Locomotion in exercised and nonexercised cats cordotomized at two or twelve weeks of age. Exp Neurol 76: 343–414Google Scholar
  36. Stelzner DJ, Ershler WB, Weber ED (1975) Effects of spinal transection in neonatal and weanling rats: survival of function. Exp Neurol 46: 156–177Google Scholar
  37. Stelzner DJ, Weber ED, Prendergast J (1979) A comparison of the effect of mid-thoracic spinal hemisection in the neonatal or weanling rat on the distribution and density of dorsal root axons in the lumbosacral spinal cord of the adult. Brain Res 172: 407–426Google Scholar
  38. Thor KB, Kuo DC, deGroat WC, Biais D, Backes M (1982) Alterations of HRP-labeled pudendal nerve afferent projections in the sacral spinal cord of the cat during neonatal development and after spinal cord transection: correlation with physiological plasticity of a spinal somatovesical reflex. Soc Neurosci Abstr 8: 305Google Scholar
  39. Viala D, Viala G, Fayein N (1985) Plasticity of locomotor organization in infant rabbits spinalized shortly after birth. In: Goldberger ME et al. (eds) Development and plasticity of the mammalian spinal cord. Liviana Press (in press)Google Scholar
  40. Wilson VJ (1962) Reflex transmission in the kitten. J Neurophysiol 25: 263–276Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • G. A. Robinson
    • 1
  • M. E. Goldberger
    • 1
  1. 1.Department of AnatomyThe Medical College of Pennsylvania/EPPI DivisionPhiladelphiaUSA

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