Gall-bladder and colonic retention of SeHCAT: a re-evaluation
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Abstract
A number of suggested alternatives and emendations to the 7-day SeHCAT retention test have been compared with whole-body counting. It was found that correction for colonic retention is an unnecessary complication in patients with diarrhoea and that imaging either of the gall-bladder or of the distribution of activity in the intestines at 24 h does not add useful information to the standard 7-day retention measurement. Neither could the patterns of colonic uptake identified in patients following extensive ideal resection or radiotherapy be reproduced in patients with idiopathic diarrhoea. Sadly it must be concluded that neither of these shortened techniques is of clinical value in patients with intact small bowel and that there remains no reliable alternative to the 7-day Se HCAT retention test. The simplest technique the best.
Key words
Seven-day SeHCAT retention Gall-bladder ColonPreview
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References
- 1.Merrick MV. Bile acid malabsorption: clinical presentations and diagnosis. Dig Dis 1988; 6: 159–169.Google Scholar
- 2.Williams AJK, Merrick MV, Eastwood MA. Idiopathic bile acid malabsorption — a review of clinical presentation, diagnosis, and response to treatment. Gut 1991; 32: 1004–1006.Google Scholar
- 3.Ferraris R, Jazrawi R, Bridges C, Northfield TC. Use of a γ-labelled bile acid (75SeHCAT) as a test of ileal function. Method of improving accuracy. Gastroenterology 1986; 90: 1129–1136.Google Scholar
- 4.Smith T, Bjarnason I. Experience with gastrointestinal marker (51CrCl3) in a combined study of ileal function using 75SeHCAT and 58CoB12 measured by whole body counting. Gut 1990; 31: 1220–1125.Google Scholar
- 5.Valdes Olmos R, Jager Fden V, Hoefnagel C, Taal B. Effect of loperamide and delay of bowel motility on bile acid malabsorption caused by late radiation damage and ileal resection. Eur J Nucl Med 1991; 18: 346–350.Google Scholar
- 6.Merrick MV, Eastwood MA, Ford MJ. Is bile acid malabsorption under diagnosed? An evaluation of accuracy of diagnosis by measurement of SeHCAT retention. Br Med J 1985; 290: 665–668.Google Scholar
- 7.Merrick MV, Eastwood MA, Anderson JR, Ross HMcL. Enterohepatic circulation in man of a gamma emitting bile acid conjugate, 23-selena-25-homotaurocholate (SeHCAT). J Nucl Med 1982; 23: 126–130.Google Scholar