Experimental Brain Research

, Volume 64, Issue 2, pp 316–334 | Cite as

M.I.T./Canadian vestibular experiments on the Spacelab-1 mission: 4. Space motion sickness: symptoms, stimuli, and predictability

  • C. M. Oman
  • B. K. Lichtenberg
  • K. E. Money
  • R. K. McCoy


Space sickness symptoms were observed by 4 specially trained observers on Spacelab-1. Three reported persistent symptoms, and vomited repeatedly during the first and/or second day of flight. Head movements on all axes were provocative, particularly in pitch and roll. Head acceleration data recorded from 2 symptomatic crewmen showed that after several hours of physical activity in orbit, symptoms appeared, and thereafter both crewmen were compelled to limit head movements. Firm body contact with motionless surfaces helped alleviate symptoms. When crewmembers floated into unfamiliar body orientations in the cabin, inherent ambiguities in static visual orientation cues sometimes produced spatial reorientation episodes which were also provocative. Symptoms largely resembled those of other forms of prolonged motion sickness, superimposed upon other symptoms attributable to fluid shift. All 4 eventually used anti-motion sickness drugs. When they did, vomiting frequency was reduced. By the 4th day, symptoms subsided, and head accelerations again increased in magnitude and variability. Sickness intensity in orbit was not predicted by statistically concordant results of 6 acute preflight susceptibility tests. However, results from a longer duration preflight prism goggles test showed an apparent correlation. All subjects were asymptomatic making head movements in parabolic flight 4 days after the mission, but not 1 year later. Overall, results support the view that space sickness is a motion sickness.

Key words

Space motion sickness Spatial orientation Vision Head movements Vomiting 


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  1. Asch SE, Witkin HA (1948) Studies in space orientation. II. Perception of the upright with displaced visual fields and with body tilted. J Exp Psychol 38: 455–477Google Scholar
  2. Benson AJ (1977) Possible mechanisms of motion and space sickness. In: Life Science Research in Space, Proc. of Cologne/Porz Symposium, ESA SP-130Google Scholar
  3. Bock OL, Oman CM (1982) Dynamics of subjective discomfort in motion sickness as measured with a magnitude estimation method. Aviat Space Env Med 53: 773–777Google Scholar
  4. Brown H (1963) The applied anatomy of vomiting. Br J Anesth 35: 137Google Scholar
  5. Chinn HI, Smith PK (1955) Motion sickness. Pharmacol Rev 7: 33–82Google Scholar
  6. Claremont CA (1931) The psychology of seasickness. Psyche 11: 86–90Google Scholar
  7. Cooper HSF (1976) A house in space. Holt, Rinehart, & Winston, New YorkGoogle Scholar
  8. Desnoes P (1926) Seasickness, JAMA 86: 322Google Scholar
  9. Eversmann T, Gottsmann M, Uhlich E, Ulbrecht G, von Werder K, Scriba PC (1978) Increased sectetion of growth hormone, prolactin, antidiuretic hormone, and cortisol induced by the stress of motion sickness. Aviat Space Env Med 49: 53–57Google Scholar
  10. Gerathewol SJ (1956) Personal experiences during short periods of weightlessness reported by 16 Subjects. Astronautica Acta 2: 203–217Google Scholar
  11. Graybiel A, Kellogg RS (1967) The inversion illusion and its probable dependence on otolith function. Aerospace Med 38: 1099–1103Google Scholar
  12. Graybiel A (1975) Angular velocities, angular accelerations, and coriolis accelerations. In: Foundations of space biology and medicine, Vol II, Book 1, Chap 7. NASA/USSR Academy of Sciences, Washington DCGoogle Scholar
  13. Graybiel A, Knepton J (1976) Sopite syndrome: a sometimes sole manifestation of motion sickness. Aviat Space Env Med 47: 873–882Google Scholar
  14. Graybiel A, Wood CD, Miller EF, Cramer DB (1968) Diagnostic criteria for grading the severity of acute motion sickness. Aerospace Med 39: 453–455Google Scholar
  15. Graybiel A, Miller EF, Homick JL (1977) Experiment M131: human vestibular function. In: Johnston RS, Deitlein LF (eds) Biomedical results from skylab, Chap 11. NASA SP-377Google Scholar
  16. Guedry FE (1978) Visual conteraction of nauseogenic and disorienting effects of some whole body motions — a proposed mechanism. Aviat Space Env Med 49: 36–41Google Scholar
  17. Held R (1961) Exposure history as a factor in maintaining stability of perception and coordination. J Nerv Ment Dis 132: 26–32Google Scholar
  18. Homick JL, Miller EF (1975) Apollo flight crew vestibular assessment. In: Johnston RS, Deitlein LF (eds) Biomedical results of apollo, Chap 8. NASA SP 368Google Scholar
  19. Homick JL, Reschke MF, Kohl RL, Degioanni J, Cintron-Trevino NM (1983) Transdermal scopolamine in prevention of motion sickness: evaluation of the time course of efficacy. Aviat Space Env Med 54: 994–1000Google Scholar
  20. Homick JL, Reschke MF, Vanderploeg JM (1984) Space adaptation syndrome: incidence and operational implications for the space transportation system program, NATO AGARD Symposium on Motion Sickness: Mechanisms, Prediction, Prevention and Treatment, Williamsburg, VA, Paper 36, AGARD CP-372Google Scholar
  21. Howard IP (1982) Human visual orientation. Wiley, TorontoGoogle Scholar
  22. Lackner JR, Graybiel A (1983) Perceived orientation in free fall depends on visual, postural, and architectural factors. Aviat Space Env Med 54: 43–51Google Scholar
  23. Lansberg MP (1960) A primer of space medicine, Chap 5. Elsevier, AmsterdamGoogle Scholar
  24. Leger A, Money KE, Landolt JP, Cheung RS, Rodden BE (1981) Motion sickness caused by rotations about earth horizontal and earth vertical axes. J Appl Physiol Resp Env Exerc Physiol 50: 469–477Google Scholar
  25. Maitland T (1931) General observations on sea sickness and the labyrinthine theory. Br Med J 1: 171–177Google Scholar
  26. Matsnev EI (1980) Mechanisms for vestibular disorders in space flight: facts and hypotheses. NASA TM-76469, NASA, Washington, DCGoogle Scholar
  27. Matsnev EI, Yakovleva IY, Tarasov IK, Alekseev VN, Kornilova LN, Mateev AD, Gorgiladze GI (1983) Space motion sickness: phenomenology, countermeasures, and mechanisms. Aviat Space Env 54: 312–317Google Scholar
  28. Melvill Jones G (1974) Adaptive neurobiology in space flight. Proc Skylab Life Sciences Symposium, Vol 2. NASA TMX-58154Google Scholar
  29. Miller AD, Wilson VJ (1983a) Vestibular-induced vomiting after vestibulo-cerebellar lesions. In: Mechanisms of motion induced vomiting. Brain Behav Evol 23: 26–31Google Scholar
  30. Miller AD, Wilson VJ (1983b) Vomiting center reanalyzed: an electrical stimulation study. Brain Res 270: 154–158Google Scholar
  31. Miller EF, Graybiel A (1970) A provocative test for grading susceptability to motion sickness yielding a single numerical score. Acta Otolaryngol Suppl 274Google Scholar
  32. Money KE (1970) Motion sickness. Physiol Rev 50: 1–39Google Scholar
  33. Money KE, Oman CM (1983) Medical monitoring and therapy of space motion sickness. In: Napolitano L (ed) Space 2000, 311–326. AIAA, New YorkGoogle Scholar
  34. Money KE, Watt DGD, Oman CM (1984) Preflight and postflight motion sickness testing of the spacelab-1 crew. NATO-AGARD Symposium on Motion Sickness: Mechanisms, Prediction, Prevention and Treatment, Williamsburg, VA, Paper 33, AGARD CP-372Google Scholar
  35. Moore HJ, Lentz JM, Guedry FE Jr (1977) Nauseogenic visual-vestibular interaction in a visual search task. NAMRL Rep 1234, Naval Aerospace Medical Research Laboratory, Pensacola, FLGoogle Scholar
  36. Oman CM (1982a) A heuristic mathematical model for the dynamics of sensory conflict and motion sickness. Acta Otolaryng Suppl 392Google Scholar
  37. Oman CM (1982b) Space motion sickness and vestibular experiments in spacelab. SAE Tech. Paper 820833; 12th Intersoc. Soc Autom Eng Conf. on Environmental Systems, San Diego CAGoogle Scholar
  38. Oman CM, Lichtenberg BK, Money KE (1984) Space motion sickness monitoring experiment: spacelab 1. NATO AGARD Symposium on Motion Sickness: Mechanisms, Prediction, Prevention and Treatment, Williamsburg, VA, Paper 35, AGARD CP-372Google Scholar
  39. Oman C, Bock O, Huang J (1980) Visually induced self motion adapts rapidly to left right visual reversal. Science 209: 706–708Google Scholar
  40. Parker D, Ivarsson A, Gulledge W, Poston R (1983) Physiological and behavioral effects of tilt induced body fluid shifts. Aviat Space Env Med 54: 402–409Google Scholar
  41. Reason JT (1978) Motion sickness adaptation: a neural mismatch model. J R Soc Med 71: 819–829Google Scholar
  42. Reason JT, Brand JJ (1975) Motion sickness. Academic Press, LondonGoogle Scholar
  43. Reschke MF, Homick JL, Ryan P, Moseley EC (1984) Prediction of the space adaptation syndrome. Proc. NATO AGARD Symposium on Motion Sickness, Williamsburg, VA, Paper 36, AGARD CP-372Google Scholar
  44. Simons DG (1955) Review of biological effects of subgravity and weightlessness. Jet Propulsion 25: 209–211Google Scholar
  45. Steele JE (1963) Motion sickness and spatial perception: a theoretical study. Aerospace Med Lab, Wright Patterson AFB, Ohio, USA AMRL-TDR-63-25Google Scholar
  46. Stevens SS (1957) On the psychophysical law. Psychol Rev 64: 153–184Google Scholar
  47. Talbot JM (1983) Research opportunities in space motion sickness. NASA CR 3708Google Scholar
  48. Thornton WE (1983) DSO 417 Inflight Countermeasures for SAS. Space Adaptation Research Project STS-8 Summary Report, December 19, 1983, NASA Johnson Space Center, Houston TXGoogle Scholar
  49. Tyler DB, Bard P (1949) Motion sickness. Physiol Rev 29: 311–369Google Scholar
  50. Witkin HA, Asch SE (1948) Studies in space orientation. IV. Further experiments on perception of the upright with displaced visual fields. J Exp Psychol 38: 762–782Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • C. M. Oman
    • 1
  • B. K. Lichtenberg
    • 1
  • K. E. Money
    • 2
  • R. K. McCoy
    • 1
  1. 1.Man-Vehicle Laboratory, Department of Aeronautics and AstronauticsMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Defence and Civil Institute of Environmental MedicineDownsviewCanada

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