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Experimental Brain Research

, Volume 39, Issue 2, pp 239–240 | Cite as

Specific calcium-dependent release of endogenous glutamate from rat striatum is reduced by destruction of the cortico-striatal tract

  • G. J. Rowlands
  • P. J. Roberts
Research Notes

Summary

Rat neostriatal slices exhibited a Ca2+-dependent release of endogenous glutamate when depolarized by elevated K+. This evoked release was reduced by 30% in tissue from animals subjected to fronto-parietal lesions 3 weeks previously. These results support the proposal that glutamate is the transmitter of the cortico-striatal pathway.

Key words

Striatum Glutamate release Cortex ablation 

References

  1. Divac I, Fonnum F, Storm-Mathisen J (1977) High-affinity uptake of glutamate in terminals of cortico-striatal axons. Nature (Lond) 266: 377–378Google Scholar
  2. Fonnum F, Malthe-Sørenssen D, Skrede K, Walaas I (1979) Glutamergic neurons: Localization, release and metabolism. Transact. VII. Meeting Int. Soc. Neurochem. p 111Google Scholar
  3. Graham LT, Jr, Aprison MH (1966) Fluorometric determination of aspartate, glutamate, and gamma-aminobutyrate in nerve tissue using enzymic methods. Analyt Biochem 15: 487–497Google Scholar
  4. Hamberger A, Chiang G, Nylén ES, Schaff SW, Cotman CW (1978) Stimulus evoked increase in the biosynthesis of the putative neurotransmitter glutamate in the hippocampus. Brain Res 143: 549–555Google Scholar
  5. Kim J-S, Hassler R, Haug P, Paik KS (1977) Effect of frontal cortex lesion on striatal glutamic acid levels in rat. Brain Res 132: 370–374Google Scholar
  6. McGeer EG, McGeer PL, Hattori T (1979) Glutamate in the striatum. In: Glutamic acid: Advances in biochemistry and physiology. Filer Jr, LJ, Garattini S, Kare MK, Reynolds W Ann, Wurtmann RJ (eds) Raven Press, New York, pp 187–201Google Scholar
  7. McGeer PL, McGeer EG, Scherer U, Singh K (1977) A glutamatergic corticostriatal path? Brain Res 128: 369–373Google Scholar
  8. Reubi JC, Cuénod M (1979) Glutamate release in vitro from cortico-striatal terminals. Brain Res 176: 185–188Google Scholar
  9. Spencer HJ (1976) Antagonism of cortical excitation of striatal neurones by glutamic acid diethylester: evidence for glutamic acid as an excitatory transmitter in the rat striatum. Brain Res 102: 91–101Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • G. J. Rowlands
    • 1
  • P. J. Roberts
    • 1
  1. 1.School of Biochemical and Physiological Sciences, Department of Physiology and PharmacologyUniversity of SouthamptonSouthamptonGreat Britain

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