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Experimental Brain Research

, Volume 65, Issue 2, pp 421–426 | Cite as

Anatomical and electrophysiological evidence for a direct projection from ammon's horn to the medial prefrontal cortex in the rat

  • F. Ferino
  • A. M. Thierry
  • J. Glowinski
Article

Summary

Following microinjection of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) into the medial prefrontal cortex (defined as the neocortical area innervated by the thalamic mediodorsal nucleus) labelled cells were observed in the pyramidal layer of the CA1 field of Ammon's horn. Observations made using antidromic stimulation confirmed these results, and revealed the slow conduction velocity of the fibres of the hippocampal cells innervating the prefrontal cortex. Taken together, these data provide evidence for a direct projection of CA1 cells to the medial prefrontal cortex.

Key words

Prefrontal cortex Ammon's horn CA1 WGA-HRP Antidromic stimulation method Rat 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • F. Ferino
    • 1
  • A. M. Thierry
    • 1
  • J. Glowinski
    • 1
  1. 1.Chaire de NeuropharmacologieCollège de France — INSERM U 114Paris Cédex 05France

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