Experimental Brain Research

, Volume 62, Issue 3, pp 663–668 | Cite as

Increased Ca-uptake of presynaptic terminals during long-term potentiation in hippocampal slices

  • D. V. Agoston
  • U. Kuhnt
Research Note


A combined electrophysiological and neurochemical study was performed on the CA1 area of hippocampal slices in an attempt to identify changes in presynaptic nerve terminal function in long-term potentiation (LTP). After controlled induction of LTP in CA1, the activated region was subjected to subcellular fractionation followed by 45Ca2+ uptake determinations. Synaptosomes prepared from slices in which LTP has been induced showed a faster risetime and a higher level of saturation for K+-induced Ca-uptake than those derived from unstimulated and stimulated control slices. These findings point to a participation of presynaptic terminals in long-term potentiation.

Key words

CA1 Hippocampus Long-term potentiation Ca-uptake Subcellular fractionation Presynaptic terminals 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • D. V. Agoston
    • 1
  • U. Kuhnt
    • 1
    • 2
  1. 1.Abteilung Neurochemie Max-Planck-Institut für Biophysikalische ChemieGöttingenFederal Republic of Germany
  2. 2.Abteilung NeurobiologieMax-Planck-Institut für Biophysikalische ChemieGöttingenFederal Republic of Germany

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