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Experimental Brain Research

, Volume 8, Issue 4, pp 295–310 | Cite as

Feeding and drinking following stimulation of the diencephalon of the monkey with amines and other substances

  • L. G. Sharpe
  • R. D. Myers
Article

Summary

In over 400 micro-injection experiments involving 70 loci within the brain stem of the conscious rhesus monkey (M. mulatta), the diencephalon was mapped in relation to changes in ingestive and other responses to chemical stimulation. Norepinephrine, in a wide range of doses, elicited eating and drinking in the satiated monkey when injected into the anterior-preoptic region, lateral hypothalamus, zona incerta, rostral tegmentum and the periventricular gray region medial to the ventromedial hypothalamus. Other compounds, in order of their potency, which produced ingestive responses were epinephrine, dopamine and serotonin (5-HT).

Application of cholinergic substances to these same loci did not produce drinking or eating in the satiated monkey. Instead, ingestive responses were blocked in a dose dependent fashion, when carbachol, acetylcholine, and eserine were microinjected into the diencephalon of the hungry and/or thirsty monkey. This cholinergic inhibition was reversible by atropine injected at the same sites. Attempts to produce excessive water intake without eating were relatively unsuccessful when compounds were micro-injected into the hypothalamus of the fully satiated monkey. The type of neurochemical “coding” system for the central nervous system mediation of many vital bodily functions thus appears to differ widely among the species tested thus far.

Key words

Chemical stimulation Eating Drinking Hypothalamus Neurochemical code Cholinergic stimulation Amines and feeding 

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Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • L. G. Sharpe
    • 1
    • 2
  • R. D. Myers
    • 1
  1. 1.Laboratory of NeuropsychologyPurdue UniversityLafayetteUSA
  2. 2.Department of PsychiatryWashington University School of MedicineSt. LouisUSA

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